Literature DB >> 27282559

A Systematic Review and Meta-Synthesis of Patients' Experiences and Perceptions of Seeking and Using Benzodiazepines and Z-Drugs: Towards Safer Prescribing.

Coral Sirdifield1, Susan Y Chipchase2, Sara Owen3, Aloysius Niroshan Siriwardena4.   

Abstract

BACKGROUND: Benzodiazepines and Z-drugs are used to treat complaints like insomnia, anxiety and pain. These drugs are recommended for short-term use only, but many studies report long-term use, particularly in older people.
OBJECTIVE: The aim of this study was to identify and synthesise qualitative studies exploring patients' experiences and perceptions of receiving benzodiazepines and Z-drugs, and through this identify factors which perpetuate use of these drugs, and strategies for achieving safer prescribing.
METHODS: A systematic search of six databases for qualitative studies exploring patients' experiences and perceptions of primary care benzodiazepine and z-drug prescribing published between January 2000 and April 2014 in a European language, and conducted in Europe, the United States, Australia or New Zealand. Reference lists of included papers were also searched. Study quality was assessed using the Critical Appraisal Skills Programme qualitative checklist. Findings were synthesised using thematic synthesis.
RESULTS: Nine papers were included and seven analytical themes were identified relating to patients' experiences and perceptions and, within that, strategies for safer prescribing of benzodiazepines and Z-drugs: (1) patients' negative perceptions of insomnia and its impact, (2) failed self-care strategies, (3) triggers to medical help-seeking, (4) attitudes towards treatment options and service provision, (5) varying patterns of use, (6) withdrawal, (7) reasons for initial or ongoing use.
CONCLUSIONS: Inappropriate use and prescribing of benzodiazepines and Z-drugs is perpetuated by psychological dependence, absence of support and patients' denial/lack of knowledge of side effects. Education strategies, increased availability of alternatives, and targeted extended dialogue with patients could support safer prescribing.

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Year:  2017        PMID: 27282559     DOI: 10.1007/s40271-016-0182-z

Source DB:  PubMed          Journal:  Patient        ISSN: 1178-1653            Impact factor:   3.883


  27 in total

1.  The diagnosis and management of benzodiazepine dependence.

Authors:  Heather Ashton
Journal:  Curr Opin Psychiatry       Date:  2005-05       Impact factor: 4.741

2.  Help-seeking for insomnia among adult patients in primary care.

Authors:  James E Aikens; Mary E Rouse
Journal:  J Am Board Fam Pract       Date:  2005 Jul-Aug

3.  Efficacy and Cost-effectiveness of Acceptance and Commitment Therapy and Applied Relaxation for Longstanding Pain: A Randomized Controlled Trial.

Authors:  Mike K Kemani; Gunnar L Olsson; Mats Lekander; Hugo Hesser; Erik Andersson; Rikard K Wicksell
Journal:  Clin J Pain       Date:  2015-11       Impact factor: 3.442

4.  Patients' and clinicians' experiences of consultations in primary care for sleep problems and insomnia: a focus group study.

Authors:  Jane V Dyas; Tanefa A Apekey; Michelle Tilling; Roderick Ørner; Hugh Middleton; A Niroshan Siriwardena
Journal:  Br J Gen Pract       Date:  2010-05       Impact factor: 5.386

Review 5.  A meta-synthesis of potentially inappropriate prescribing in older patients.

Authors:  Shane Cullinan; Denis O'Mahony; Aoife Fleming; Stephen Byrne
Journal:  Drugs Aging       Date:  2014-08       Impact factor: 3.923

6.  Epidemiology of insomnia: prevalence, self-help treatments, consultations, and determinants of help-seeking behaviors.

Authors:  C M Morin; M LeBlanc; M Daley; J P Gregoire; C Mérette
Journal:  Sleep Med       Date:  2006-02-03       Impact factor: 3.492

7.  Help-seeking behaviour in patients with anxiety disorder and depression.

Authors:  A Roness; A Mykletun; A A Dahl
Journal:  Acta Psychiatr Scand       Date:  2005-01       Impact factor: 6.392

Review 8.  Patient barriers to and enablers of deprescribing: a systematic review.

Authors:  Emily Reeve; Josephine To; Ivanka Hendrix; Sepehr Shakib; Michael S Roberts; Michael D Wiese
Journal:  Drugs Aging       Date:  2013-10       Impact factor: 3.923

9.  Computer therapy for the anxiety and depressive disorders is effective, acceptable and practical health care: a meta-analysis.

Authors:  Gavin Andrews; Pim Cuijpers; Michelle G Craske; Peter McEvoy; Nickolai Titov
Journal:  PLoS One       Date:  2010-10-13       Impact factor: 3.240

10.  Adherence to Technology-Mediated Insomnia Treatment: A Meta-Analysis, Interviews, and Focus Groups.

Authors:  Corine Horsch; Jaap Lancee; Robbert Jan Beun; Mark A Neerincx; Willem-Paul Brinkman
Journal:  J Med Internet Res       Date:  2015-09-04       Impact factor: 5.428

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  21 in total

1.  The anxiolytic-like effect of 6-styryl-2-pyrone in mice involves GABAergic mechanism of action.

Authors:  Edna Maria Camelo Chaves; Jose Eduardo Ribeiro Honório-Júnior; Caren Nádia Soares Sousa; Valdécio Silveira Monteiro; Dayanne Terra Tenório Nonato; Leonardo Pimentel Dantas; Ana Silvia Suassuna Carneiro Lúcio; José Maria Barbosa-Filho; Manoel Cláudio Azevedo Patrocínio; Glauce Socorro Barros Viana; Silvânia Maria Mendes Vasconcelos
Journal:  Metab Brain Dis       Date:  2017-10-30       Impact factor: 3.584

Review 2.  Deprescribing Benzodiazepines in Older Patients: Impact of Interventions Targeting Physicians, Pharmacists, and Patients.

Authors:  Brendan J Ng; David G Le Couteur; Sarah N Hilmer
Journal:  Drugs Aging       Date:  2018-06       Impact factor: 3.923

3.  Patient Preferences for Managing Insomnia: A Discrete Choice Experiment.

Authors:  Janet M Y Cheung; Delwyn J Bartlett; Carol L Armour; Bandana Saini; Tracey-Lea Laba
Journal:  Patient       Date:  2018-10       Impact factor: 3.883

4.  Comparison of the prevalence and nature of potentially inappropriate medication use in geriatric outpatients between tertiary and community healthcare settings: a multicenter cross-sectional study.

Authors:  Yan Zeng; Yongpei Yu; Qingyang Liu; Su Su; Yang Lin; Hongyan Gu; Shicai Chen; Pengmei Li; Tong Xu; Naizhao Sun; Tao Lin; Qian Huang; Yujie Fan; Fengzhi Wang; Suying Yan
Journal:  Int J Clin Pharm       Date:  2022-02-25

5.  Insomnia in Older Adults.

Authors:  Vivian Nguyen; Tessy George; Glenna S Brewster
Journal:  Curr Geriatr Rep       Date:  2019-10-22

6.  Trends in benzodiazepine receptor agonists use and associated factors in the Belgian general older population: analysis of the Belgian health interview survey data.

Authors:  Catherine Pétein; Anne Spinewine; Séverine Henrard
Journal:  Ther Adv Psychopharmacol       Date:  2021-05-25

7.  Role of the prescriber in supporting patients to discontinue benzodiazepines: a qualitative study.

Authors:  Erin Oldenhof; Timothy Mason; Jane Anderson-Wurf; Petra K Staiger
Journal:  Br J Gen Pract       Date:  2021-06-24       Impact factor: 6.302

8.  Teaching young GPs to cope with psychosocial consultations without prescribing: a durable impact of an e-module on determinants of benzodiazepines prescribing.

Authors:  Hanne Creupelandt; Sibyl Anthierens; Hilde Habraken; Tom Declercq; Coral Sirdifield; Aloysius Niroshan Siriwardena; Thierry Christiaens
Journal:  BMC Med Educ       Date:  2017-12-19       Impact factor: 2.463

9.  Administration of Alphas1-Casein Hydrolysate Increases Sleep and Modulates GABAA Receptor Subunit Expression.

Authors:  Taddesse Yayeh; Yea-Hyun Leem; Kyung-Mi Kim; Jae-Chul Jung; Jessica Schwarz; Ki-Wan Oh; Seikwan Oh
Journal:  Biomol Ther (Seoul)       Date:  2018-05-01       Impact factor: 4.634

10.  "It could potentially be dangerous... but nothing else has seemed to help me.": Patient and clinician perspectives on benzodiazepine use in opioid agonist treatment.

Authors:  Tae Woo Park; Jennifer Sikov; Vanessa dellaBitta; Richard Saitz; Alexander Y Walley; Mari-Lynn Drainoni
Journal:  J Subst Abuse Treat       Date:  2021-04-30
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