| Literature DB >> 27282376 |
Yang Yang1,2,3, Zhiqiang Ma4, Wei Hu2, Dongjin Wang3, Shuai Jiang5, Chongxi Fan4, Shouyin Di4, Dong Liu6, Yang Sun7, Wei Yi8.
Abstract
Myocardial ischemia/reperfusion (I/R) injury is a major cause of morbidity and mortality worldwide. Caveolae, caveolin-1 (Cav-1), and caveolin-3 (Cav-3) are essential for the protective effects of conditioning against myocardial I/R injury. Caveolins are membrane-bound scaffolding proteins that compartmentalize and modulate signal transduction. In this review, we introduce caveolae and caveolins and briefly describe the interactions of caveolins in the cardiovascular diseases. We also review the roles of Cav-1/-3 in protection against myocardial ischemia and I/R injury, and in conditioning. Finally, we suggest several potential research avenues that may be of interest to clinicians and basic scientists. The information included, herein, is potentially useful for the design of future studies and should advance the investigation of caveolins as therapeutic targets.Entities:
Keywords: Cardioprotection; Caveolins; Myocardial ischemia
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Year: 2016 PMID： 27282376 DOI： 10.1007/s00395-016-0561-6
Source DB: PubMed Journal: Basic Res Cardiol ISSN： 0300-8428 Impact factor: 17.165