Literature DB >> 27281567

Pain and Itch: Beneficial or Harmful to Antimicrobial Defense?

Pankaj Baral1, Kimbria Mills1, Felipe A Pinho-Ribeiro1, Isaac M Chiu2.   

Abstract

Pain and itch are unpleasant sensations accompanying many microbial infections. Recent studies demonstrate that pain- and itch-mediating somatosensory neurons are able to directly detect pathogens, triggering neuronal activation and subsequent regulation of immune responses. We discuss whether pain and/or itch during infection is beneficial or harmful to host antimicrobial defense.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  host defense; itch; neuroimmunology; pain

Mesh：

Year:  2016        PMID： 27281567     DOI： 10.1016/j.chom.2016.05.010

Source DB:  PubMed          Journal:  Cell Host Microbe        ISSN： 1931-3128            Impact factor:   21.023


  16 in total

1.  An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk.

Authors:  Nissan Yissachar; Yan Zhou; Lloyd Ung; Nicole Y Lai; James F Mohan; Allen Ehrlicher; David A Weitz; Dennis L Kasper; Isaac M Chiu; Diane Mathis; Christophe Benoist
Journal:  Cell       Date:  2017-03-02       Impact factor: 41.582

Review 2.  Infection, Pain, and Itch.

Authors:  Isaac M Chiu
Journal:  Neurosci Bull       Date:  2017-01-31       Impact factor: 5.203

Review 3.  Bacterial Signaling to the Nervous System through Toxins and Metabolites.

Authors:  Nicole J Yang; Isaac M Chiu
Journal:  J Mol Biol       Date:  2017-01-06       Impact factor: 5.469

Review 4.  THE SKIN MICROBIOTA AND ITCH: Is There a Link?

Authors:  Hei Sung Kim; Gil Yosipovitch
Journal:  J Clin Aesthet Dermatol       Date:  2020-06-01

Review 5.  Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation.

Authors:  Felipe A Pinho-Ribeiro; Waldiceu A Verri; Isaac M Chiu
Journal:  Trends Immunol       Date:  2016-10-25       Impact factor: 16.687

6.  TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms.

Authors:  Xiuhua Miao; Ya Huang; Teng-Teng Liu; Ran Guo; Bing Wang; Xue-Long Wang; Li-Hua Chen; Yan Zhou; Ru-Rong Ji; Tong Liu
Journal:  Neurosci Bull       Date:  2017-04-01       Impact factor: 5.203

7.  Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress in Pruritus.

Authors:  Feng-Ming Zhou; Ruo-Xiao Cheng; Shuai Wang; Ya Huang; Yong-Jing Gao; Yan Zhou; Teng-Teng Liu; Xue-Long Wang; Li-Hua Chen; Tong Liu
Journal:  Neurosci Bull       Date:  2016-10-25       Impact factor: 5.203

8.  Type I Interferons Act Directly on Nociceptors to Produce Pain Sensitization: Implications for Viral Infection-Induced Pain.

Authors:  Paulino Barragán-Iglesias; Úrzula Franco-Enzástiga; Vivekanand Jeevakumar; Stephanie Shiers; Andi Wangzhou; Vinicio Granados-Soto; Zachary T Campbell; Gregory Dussor; Theodore J Price
Journal:  J Neurosci       Date:  2020-04-03       Impact factor: 6.167

Review 9.  Pain and immunity: implications for host defence.

Authors:  Pankaj Baral; Swalpa Udit; Isaac M Chiu
Journal:  Nat Rev Immunol       Date:  2019-07       Impact factor: 53.106

Review 10.  Th2 Modulation of Transient Receptor Potential Channels: An Unmet Therapeutic Intervention for Atopic Dermatitis.

Authors:  Jianghui Meng; Yanqing Li; Michael J M Fischer; Martin Steinhoff; Weiwei Chen; Jiafu Wang
Journal:  Front Immunol       Date:  2021-06-30       Impact factor: 7.561
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