| Literature DB >> 27281451 |
Yi Gong1, Tingxi Zhan1, Qing Li1, Guozhen Zhang1, Bing Tan1, Xiaoliang Yang1, Yan Wu1, Wenjuan Que1, Yan Xing1, Hui Liu1, Xue Hu1, Zebo Yu2.
Abstract
Progranulin (PGRN) is implicated in infection, immunity and host defense, but its role in the pathogenesis of HBV infection remains unknown. Here we investigated whether there is dysregulated production and the clinical significance of circulating PGRN in patients with chronic HBV infection. Serum concentrations of PGRN were analyzed by enzyme-linked immunosorbent assay. Serum PGRN levels were significantly higher in patients with chronic HBV infection than healthy subjects. PGRN levels were significantly associated with HBV-DNA levels, but did not correlate with the concentrations of alanine aminotransferase and aspartate aminotransferase. This study demonstrates increased circulating PGRN production and association between PGRN levels and viral loads in patients with chronic HBV infection, suggesting a functional role of PGRN in the pathogenesis of HBV infection.Entities:
Keywords: Growth factor; HBV; Infection; Patients; Progranulin
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Year: 2016 PMID： 27281451 DOI： 10.1016/j.cyto.2016.05.026
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861