Literature DB >> 2727949

The propagation of uncertainty in human mortality processes operating in stochastic environments.

A I Yashin1, K G Manton, E Stallard.   

Abstract

This paper presents a model describing how the uncertainty due to influential exogenous processes combines with stochasticity intrinsic to physiological aging processes and propagates through time to generate uncertainty about the future physiological state of the population. Variance expressions are derived for (a) the future values of the physiological variables under the assumption that external factors evolve under a linear stochastic diffusion process, and (b) the cohort survival functions and cohort life expectancies which reflect the uncertainty in the future values of the physiological variables. The model implies that a major component of uncertainty in forecasts of the physiological characteristics of a closed cohort is due to differential rates of survival associated with different realizations of the external process. This suggests that the limits to forecasting may be different in physiological systems subject to systematic mortality than in physical systems such as weather where the concepts of closed cohorts and of mortality selection have no simple analog.

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Year:  1989        PMID: 2727949     DOI: 10.1016/0040-5809(89)90013-0

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  5 in total

Review 1.  Frailty models for survival data.

Authors:  P Hougaard
Journal:  Lifetime Data Anal       Date:  1995       Impact factor: 1.588

Review 2.  Dynamics of biomarkers in relation to aging and mortality.

Authors:  Konstantin G Arbeev; Svetlana V Ukraintseva; Anatoliy I Yashin
Journal:  Mech Ageing Dev       Date:  2016-04-29       Impact factor: 5.432

Review 3.  Joint Analyses of Longitudinal and Time-to-Event Data in Research on Aging: Implications for Predicting Health and Survival.

Authors:  Konstantin G Arbeev; Igor Akushevich; Alexander M Kulminski; Svetlana V Ukraintseva; Anatoliy I Yashin
Journal:  Front Public Health       Date:  2014-11-06

4.  stpm: an R package for stochastic process model.

Authors:  Ilya Y Zhbannikov; Konstantin Arbeev; Igor Akushevich; Eric Stallard; Anatoliy I Yashin
Journal:  BMC Bioinformatics       Date:  2017-02-23       Impact factor: 3.169

5.  Optimal Versus Realized Trajectories of Physiological Dysregulation in Aging and Their Relation to Sex-Specific Mortality Risk.

Authors:  Konstantin G Arbeev; Alan A Cohen; Liubov S Arbeeva; Emmanuel Milot; Eric Stallard; Alexander M Kulminski; Igor Akushevich; Svetlana V Ukraintseva; Kaare Christensen; Anatoliy I Yashin
Journal:  Front Public Health       Date:  2016-01-25
  5 in total

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