Simone Barsotti1,2, Virna Zampa3, Rosaria Talarico4, Fabrizio Minichilli5, Simona Ortori3, Valentina Iacopetti4, Anna D'ascanio4, Antonio Gaetano Tavoni6, Stefano Bombardieri4, Marta Mosca4, Rossella Neri4. 1. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. simone.barsotti.pisa@gmail.com. 2. Genetic, Oncology and Clinical Medicine doctorate, University of Siena, Siena, Italy. simone.barsotti.pisa@gmail.com. 3. Department of Diagnostic and Interventional Radiology, University of Pisa, Via Roma 67, 56126, Pisa, Italy. 4. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy. 5. Unit of Environmental Epidemiology, Institute of Clinical Physiology, National Council of Research, Pisa, Italy. 6. Immunoallergology Unit, Internal Medicine, University of Pisa, Pisa, Italy.
Abstract
INTRODUCTION: In patients with idiopathic inflammatory myopathies (IIM), magnetic resonance imaging (MRI) has been proposed as a useful tool for diagnosis and follow-up. It may identify muscle inflammation (edema) and fatty infiltration for evaluation of disease activity and damage. Little information is available on the role of MRI in assessment of large cohorts of adult patients with IIM. METHODS: Fifty-one patients underwent MRI of the thigh muscles, laboratory tests, and clinical evaluation, including Physician Global Assessment (PGA) of myositis activity and the Manual Muscle Test 8 (MMT8). RESULTS: Muscle edema correlated significantly with creatine kinase values (P = 0.017) and PGA (P < 0.001). A significant correlation between edema and MMT8 values (P = 0.025) was observed when patients with muscle fatty infiltration were excluded. With respect to clinical diagnosis, the sensitivity of MRI was 92.3%, and specificity was 83.3%. CONCLUSIONS: MRI appears to provide additional information that complements clinical and biochemical examinations. Muscle Nerve 54: 666-672, 2016.
INTRODUCTION: In patients with idiopathic inflammatory myopathies (IIM), magnetic resonance imaging (MRI) has been proposed as a useful tool for diagnosis and follow-up. It may identify muscle inflammation (edema) and fatty infiltration for evaluation of disease activity and damage. Little information is available on the role of MRI in assessment of large cohorts of adult patients with IIM. METHODS: Fifty-one patients underwent MRI of the thigh muscles, laboratory tests, and clinical evaluation, including Physician Global Assessment (PGA) of myositis activity and the Manual Muscle Test 8 (MMT8). RESULTS:Muscle edema correlated significantly with creatine kinase values (P = 0.017) and PGA (P < 0.001). A significant correlation between edema and MMT8 values (P = 0.025) was observed when patients with muscle fatty infiltration were excluded. With respect to clinical diagnosis, the sensitivity of MRI was 92.3%, and specificity was 83.3%. CONCLUSIONS: MRI appears to provide additional information that complements clinical and biochemical examinations. Muscle Nerve 54: 666-672, 2016.
Authors: Lisa G Rider; Rohit Aggarwal; Pedro M Machado; Jean-Yves Hogrel; Ann M Reed; Lisa Christopher-Stine; Nicolino Ruperto Journal: Nat Rev Rheumatol Date: 2018-04-12 Impact factor: 20.543
Authors: E E Sigmund; S H Baete; T Luo; K Patel; D Wang; I Rossi; A Duarte; M Bruno; D Mossa; A Femia; S Ramachandran; D Stoffel; J S Babb; A G Franks; J Bencardino Journal: Eur Radiol Date: 2018-06-04 Impact factor: 5.315