Hiroshi Honma1, Tadaaki Ohno2, Yukichi Tokita2, Tsuyako Matsuzaki3, Hiroyuki Fujimoto2, Aya Yoshinaga2, Shoko Sato2, Tomoko Yokoshima2, Keiko Ito2, Kyoichi Mizuno2. 1. Division of Cardiology, Department of Internal Medicine, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo, Tokyo, 113-8603, Japan. hirohomma@nms.ac.jp. 2. Division of Cardiology, Department of Internal Medicine, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi, Bunkyo, Tokyo, 113-8603, Japan. 3. Laboratory of Ultrasonography, Nippon Medical School Hospital, Tokyo, Japan.
Abstract
PURPOSE: The aim of this study was to clarify the relationship between the severity of aortic valve calcification (AVC) and stiffness of the proximal thoracic ascending aorta (TAA), and to examine their influence on left ventricular (LV) function and renal function. METHODS: A total of 138 hypertensive patients including 32 with diabetes mellitus and 60 with dyslipidemia were divided into four groups based on the severity of AVC. We analyzed the elastic properties of the proximal TAA from the following strain-rate indices based on tissue Doppler imaging: maximum strain rate [SR(+)], minimum SR [SR(-)], and the time between the QRS peak and the peak SR(-) of the proximal TAA (SRT). RESULTS: SR(+) and SRT were significantly greater in patients with moderate AVC than in patients with mild AVC. SRT and SR(-) were well correlated with age, peak velocity across AV, TAA wall thickness (IMC), LV diastolic function, and renal function. SRT was independently related to IMC, dyslipidemia, and LV diastolic function. CONCLUSION: The severity of AVC was correlated with the elastic properties of the proximal TAA. The SR indices are useful for assessing the relation of TAA stiffness to LV function and renal function in patients with AVC.
PURPOSE: The aim of this study was to clarify the relationship between the severity of aortic valve calcification (AVC) and stiffness of the proximal thoracic ascending aorta (TAA), and to examine their influence on left ventricular (LV) function and renal function. METHODS: A total of 138 hypertensivepatients including 32 with diabetes mellitus and 60 with dyslipidemia were divided into four groups based on the severity of AVC. We analyzed the elastic properties of the proximal TAA from the following strain-rate indices based on tissue Doppler imaging: maximum strain rate [SR(+)], minimum SR [SR(-)], and the time between the QRS peak and the peak SR(-) of the proximal TAA (SRT). RESULTS: SR(+) and SRT were significantly greater in patients with moderate AVC than in patients with mild AVC. SRT and SR(-) were well correlated with age, peak velocity across AV, TAA wall thickness (IMC), LV diastolic function, and renal function. SRT was independently related to IMC, dyslipidemia, and LV diastolic function. CONCLUSION: The severity of AVC was correlated with the elastic properties of the proximal TAA. The SR indices are useful for assessing the relation of TAA stiffness to LV function and renal function in patients with AVC.
Entities:
Keywords:
Aortic stiffness; Aortic valve calcification; Chronic kidney dysfunction; Left ventricular diastolic function
Authors: Antonio Vitarelli; Marcello Giordano; Giuseppe Germanò; Mario Pergolini; Paolo Cicconetti; Francesco Tomei; Angela Sancini; Daniela Battaglia; Olga Dettori; Lidia Capotosto; Valentina De Cicco; Melissa De Maio; Massimo Vitarelli; Pasqualina Bruno Journal: Heart Date: 2010-07-18 Impact factor: 5.994
Authors: Valentin Fuster; Pedro R Moreno; Zahi A Fayad; Roberto Corti; Juan J Badimon Journal: J Am Coll Cardiol Date: 2005-09-20 Impact factor: 24.094
Authors: Kevin D O'Brien; Jeffrey L Probstfield; Michael T Caulfield; Khurram Nasir; Junichiro Takasu; David M Shavelle; Audrey H Wu; Xue-Qiao Zhao; Matthew J Budoff Journal: Arch Intern Med Date: 2005-04-25
Authors: Nalini M Rajamannan; Malayannan Subramaniam; David Rickard; Stuart R Stock; Janis Donovan; Margaret Springett; Thomas Orszulak; David A Fullerton; A J Tajik; Robert O Bonow; Thomas Spelsberg Journal: Circulation Date: 2003-04-28 Impact factor: 29.690
Authors: Anne B Rossebø; Terje R Pedersen; Kurt Boman; Philippe Brudi; John B Chambers; Kenneth Egstrup; Eva Gerdts; Christa Gohlke-Bärwolf; Ingar Holme; Y Antero Kesäniemi; William Malbecq; Christoph A Nienaber; Simon Ray; Terje Skjaerpe; Kristian Wachtell; Ronnie Willenheimer Journal: N Engl J Med Date: 2008-09-02 Impact factor: 91.245
Authors: Kenichi Sugioka; Takeshi Hozumi; Robert R Sciacca; Yumiko Miyake; Inna Titova; Gabrielle Gaspard; Ralph L Sacco; Shunichi Homma; Marco R Di Tullio Journal: Stroke Date: 2002-08 Impact factor: 7.914