Hui Miao1, Xingui Chen2, Yunwen Yan3, Xiaoxuan He1, Sheng Hu1, Jian Kong4, Meiqi Wu1, Yarui Wei1, Yawen Zhou1, Lu Wang1, Kai Wang5, Bensheng Qiu6,7. 1. Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, China. 2. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China. 3. Department of Breast Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. 4. Department of Psychiatry, Massachusetts General Hospital, Charlestown, MA, USA. 5. Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230022, China. wangkai1964@126.com. 6. Center for Biomedical Engineering, University of Science and Technology of China, Hefei, Anhui, China. bqiu@ustc.edu.cn. 7. Anhui Computer Application Institute of Traditional Chinese Medicine, Hefei, Anhui, 230038, China. bqiu@ustc.edu.cn.
Abstract
INTRODUCTION: Complaint about attention disorders is common among breast cancer patients who have undergone chemotherapy, which may be associated with the default mode network (DMN). To validate this hypothesis, we investigated the DMN functional connectivity (FC) change and its relationship with the attention function in breast cancer patients (BC) using resting-state functional magnetic resonance imaging (rs-fMRI). METHODS: Twenty-two BC treated with chemotherapy and 22 healthy controls (HC) were recruited into this study. The FC between the DMN's hubs and regions of the dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL) subsystems was respectively calculated for each participant. RESULTS: The statistical result showed significantly lower connectivity in dMPFC and MTL subsystems in the BC group. In addition, the partial correlation analysis result indicated that the low connectivity of some brain regions in MTL subsystem was correlated with attention dysfunction following BC chemotherapy. CONCLUSION: These results suggest that the functional disconnection in MTL subsystem of the DMN may have association with attention function of BC after chemotherapy.
INTRODUCTION: Complaint about attention disorders is common among breast cancerpatients who have undergone chemotherapy, which may be associated with the default mode network (DMN). To validate this hypothesis, we investigated the DMN functional connectivity (FC) change and its relationship with the attention function in breast cancerpatients (BC) using resting-state functional magnetic resonance imaging (rs-fMRI). METHODS: Twenty-two BC treated with chemotherapy and 22 healthy controls (HC) were recruited into this study. The FC between the DMN's hubs and regions of the dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL) subsystems was respectively calculated for each participant. RESULTS: The statistical result showed significantly lower connectivity in dMPFC and MTL subsystems in the BC group. In addition, the partial correlation analysis result indicated that the low connectivity of some brain regions in MTL subsystem was correlated with attention dysfunction following BC chemotherapy. CONCLUSION: These results suggest that the functional disconnection in MTL subsystem of the DMN may have association with attention function of BC after chemotherapy.
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