Kinya Ishizaka1, Mutsumi Nishida2,3, Makoto Motomiya4, Megumi Satoh5,3, Mamiko Inoue2,3, Yusuke Kudoh2,3, Satomi Omotehara2,3, Tatsunori Horie5,3, Tadanao Funakoshi4, Norimasa Iwasaki4. 1. Department of Radiological Technology, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan. ishizaka-kk@huhp.hokudai.ac.jp. 2. Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan. 3. Diagnostic Center for Sonography, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan. 4. Department of Orthopaedic Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. 5. Department of Radiological Technology, Hokkaido University Hospital, N14 W5, Kita-ku, Sapporo, 060-8648, Japan.
Abstract
PURPOSE: The purpose of the study was to validate the reliability of quantitative intraneural enhancement patterns by using contrast-enhanced ultrasonography (CEUS). METHODS: Nine asymptomatic wrists underwent a total of three CEUS examinations each conducted at 1-month intervals. The CEUS enhancement pattern of median nerves was quantitatively evaluated. The area under the time-intensity curve was calculated by placing the regions of interest at the proximal, center, and distal regions of the median nerve. An intra-class correlation coefficient for intra-observer, inter-observer, and inter-examination reproducibility was calculated. RESULTS: The intra- and inter-observer reproducibility was almost perfect. Inter-examination reproducibility of the proximal, center, and distal regions was 0.891, 0.614, and 0.535, respectively. In this study, we found that the reproducibility of the distal and center regions of the median nerve in the carpal tunnel was lower than that of the proximal region. CONCLUSION: High intra-observer, inter-observer, and inter-examination reproducibility of CEUS was obtained in the evaluation of the intraneural enhancement pattern when the region of interest was placed in the proximal region of the median nerve.
PURPOSE: The purpose of the study was to validate the reliability of quantitative intraneural enhancement patterns by using contrast-enhanced ultrasonography (CEUS). METHODS: Nine asymptomatic wrists underwent a total of three CEUS examinations each conducted at 1-month intervals. The CEUS enhancement pattern of median nerves was quantitatively evaluated. The area under the time-intensity curve was calculated by placing the regions of interest at the proximal, center, and distal regions of the median nerve. An intra-class correlation coefficient for intra-observer, inter-observer, and inter-examination reproducibility was calculated. RESULTS: The intra- and inter-observer reproducibility was almost perfect. Inter-examination reproducibility of the proximal, center, and distal regions was 0.891, 0.614, and 0.535, respectively. In this study, we found that the reproducibility of the distal and center regions of the median nerve in the carpal tunnel was lower than that of the proximal region. CONCLUSION: High intra-observer, inter-observer, and inter-examination reproducibility of CEUS was obtained in the evaluation of the intraneural enhancement pattern when the region of interest was placed in the proximal region of the median nerve.
Keywords:
Contrast-enhanced ultrasound; Intraneural vascularity; Median nerve; Reproducibility
Authors: Luis Alemán; Juan D Berná; Manuel Reus; Francisco Martínez; Ginés Doménech-Ratto; Matilde Campos Journal: J Ultrasound Med Date: 2008-02 Impact factor: 2.153