Liam M Heaney1,2,3, Dorota M Ruszkiewicz1, Kayleigh L Arthur1, Andria Hadjithekli1, Clive Aldcroft4, Martin R Lindley2, Cl Paul Thomas1, Matthew A Turner1, James C Reynolds1. 1. Centre for Analytical Science, Department of Chemistry, Loughborough University, Epinal Way, Loughborough, Leicestershire LE11 3TU, UK. 2. School of Sport, Exercise & Health Sciences, Loughborough University, Epinal Way, Loughborough, Leicestershire LE11 3TU, UK. 3. Department of Cardiovascular Sciences & NIHR Leicester Cardiovascular Biomedical Research Unit, University of Leicester, Glenfield Hospital, Leicester LE3 9QP, UK. 4. Advion UK Ltd, Edinburgh Way, Harlow CM20 2NQ, UK.
Abstract
AIM: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. CONCLUSION: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.
AIM: Breath analyses have potential to detect early signs of disease onset. Ambient ionization allows direct combination of breath gases with MS for fast, on-line analysis. Portable MS systems would facilitate field/clinic-based breath analyses. Results & methodology: Volunteers ingested peppermint oil capsules and exhaled volatile compounds were monitored over 10 h using a compact mass spectrometer. A rise and fall in exhaled menthone was observed, peaking at 60-120 min. Real-time analysis showed a gradual rise in exhaled menthone postingestion. Sensitivity was comparable to established methods, with detection in the parts per trillion range. CONCLUSION: Breath volatiles were readily analyzed on a portable mass spectrometer through a simple inlet modification. Induced changes in exhaled profiles were detectable with high sensitivity and measurable in real-time.
Authors: Wadah Ibrahim; Michael Wilde; Rebecca Cordell; Dahlia Salman; Dorota Ruszkiewicz; Luke Bryant; Matthew Richardson; Robert C Free; Bo Zhao; Ahmed Yousuf; Christobelle White; Richard Russell; Sheila Jones; Bharti Patel; Asia Awal; Rachael Phillips; Graham Fowkes; Teresa McNally; Clare Foxon; Hetan Bhatt; Rosa Peltrini; Amisha Singapuri; Beverley Hargadon; Toru Suzuki; Leong L Ng; Erol Gaillard; Caroline Beardsmore; Kimuli Ryanna; Hitesh Pandya; Tim Coates; Paul S Monks; Neil Greening; Christopher E Brightling; Paul Thomas; Salman Siddiqui Journal: BMJ Open Date: 2019-03-08 Impact factor: 2.692
Authors: P Perez-Hurtado; E Palmer; T Owen; C Aldcroft; M H Allen; J Jones; C S Creaser; M R Lindley; M A Turner; J C Reynolds Journal: Rapid Commun Mass Spectrom Date: 2017-11-30 Impact factor: 2.419