Malco Rossi1, Alex Medina Escobar1, Andrea Bril1, Patricio Millar Vernetti1, Juan Ignacio De Palo1, Daniel Cerquetti1, Marcelo Merello2,3. 1. Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina. 2. Movement Disorders Section, Neuroscience Department, Raul Carrea Institute for Neurological Research (FLENI), Ciudad Autónoma de Buenos Aires, Argentina. mmerello@fleni.org.ar. 3. Argentine National Scientific and Technological Research Council (CONICET), Buenos Aires, Argentina. mmerello@fleni.org.ar.
Abstract
BACKGROUND: Normosmic Parkinson's disease (PD) might be a unique clinical phenotype with a more benign course when compared with hyposmic PD. OBJECTIVE: The objective of this study was to evaluate motor features and the acute levodopa response according to olfactory function. METHODS: A total of 169 de novo PD patients that underwent olfactory testing and acute levodopa challenge for clinical prediction of sustained long-term dopaminergic response were evaluated. RESULTS: The overall frequency of normosmia was 33%. Normosmic PD patients scored nonsignificantly different to hyposmic/anosmic patients on motor scale and on degree of improvement with levodopa. Motor scores at follow-up were comparable among groups. CONCLUSIONS: Normal olfactory function is common in early PD and was not associated with a different motor phenotype when compared with PD patients with olfactory dysfunction.
BACKGROUND: Normosmic Parkinson's disease (PD) might be a unique clinical phenotype with a more benign course when compared with hyposmic PD. OBJECTIVE: The objective of this study was to evaluate motor features and the acute levodopa response according to olfactory function. METHODS: A total of 169 de novo PDpatients that underwent olfactory testing and acute levodopa challenge for clinical prediction of sustained long-term dopaminergic response were evaluated. RESULTS: The overall frequency of normosmia was 33%. Normosmic PDpatients scored nonsignificantly different to hyposmic/anosmic patients on motor scale and on degree of improvement with levodopa. Motor scores at follow-up were comparable among groups. CONCLUSIONS: Normal olfactory function is common in early PD and was not associated with a different motor phenotype when compared with PDpatients with olfactory dysfunction.
Authors: Katerina Markopoulou; Bruce A Chase; Piotr Robowski; Audrey Strongosky; Ewa Narożańska; Emilia J Sitek; Mariusz Berdynski; Maria Barcikowska; Matt C Baker; Rosa Rademakers; Jarosław Sławek; Christine Klein; Katja Hückelheim; Meike Kasten; Zbigniew K Wszolek Journal: PLoS One Date: 2016-11-17 Impact factor: 3.240
Authors: Fernando Rodriguez-Sanchez; Carmen Rodriguez-Blazquez; Concha Bielza; Pedro Larrañaga; Daniel Weintraub; Pablo Martinez-Martin; Alexandra Rizos; Anette Schrag; K Ray Chaudhuri Journal: Sci Rep Date: 2021-12-08 Impact factor: 4.379