Literature DB >> 27275869

Transition Metal Free Intermolecular Direct Oxidative C-N Bond Formation to Polysubstituted Pyrimidines Using Molecular Oxygen as the Sole Oxidant.

Wei Guo1,2, Chunsheng Li1, Jianhua Liao1, Fanghua Ji1, Dongqing Liu1, Wanqing Wu1, Huanfeng Jiang1.   

Abstract

Various polysubstituted pyrimidines are smoothly formed via a base-promoted intermolecular oxidation C-N bond formation of allylic C(sp(3))-H and vinylic C(sp(2))-H of allyllic compounds with amidines using O2 as the sole oxidant. This protocol features protecting group free nitrogen sources, good functional group tolerance, high atom economy, and environmental advantages.

Entities:  

Year:  2016        PMID： 27275869     DOI： 10.1021/acs.joc.6b00867

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

Review 1.  Research developments in the syntheses, anti-inflammatory activities and structure-activity relationships of pyrimidines.

Authors:  Haroon Ur Rashid; Marco Antonio Utrera Martines; Adriana Pereira Duarte; Juliana Jorge; Shagufta Rasool; Riaz Muhammad; Nasir Ahmad; Muhammad Naveed Umar
Journal:  RSC Adv       Date:  2021-02-03       Impact factor: 3.361

2.  Synthesis of Novel Derivatives of 5,6,7,8-Tetrahydroquinazolines Using α-Aminoamidines and In Silico Screening of Their Biological Activity.

Authors:  Arsenii D Snizhko; Alexander V Kyrychenko; Eugene S Gladkov
Journal:  Int J Mol Sci       Date:  2022-03-29       Impact factor: 5.923
  2 in total

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