Literature DB >> 27275477

Increasing incidence of colon cancer in patients <50 years old: a new entity?

Michail Karanikas1, Agis Esebidis1.   

Abstract

Colorectal cancer (CRC) is the third most common cancer type in humans, the fourth most common cause of death because of cancer, and the second most common cancer type in terms of the number of individuals living with cancer 5 years after diagnosis worldwide, almost 694,000 people die from CRC annually. As it is expected is more frequent in older patients (patients older than 70 years old than in young patients (patients younger than 40 years old). The incidence of CRC in young adults is rising the last years and this fact arises the question; is this coincidence or is young adult CRC a real epidemy. In our current commentary we try and elucidate based on current data whether disease on young individuals is a new entity.

Entities:  

Keywords:  Colon cancer; Lynch syndrome; gastrointestinal (GI)

Year:  2016        PMID: 27275477      PMCID: PMC4876259          DOI: 10.21037/atm.2016.04.13

Source DB:  PubMed          Journal:  Ann Transl Med        ISSN: 2305-5839


  24 in total

1.  Treatment and prevention of intraepithelial neoplasia: an important target for accelerated new agent development.

Authors:  Joyce A O'Shaughnessy; Gary J Kelloff; Gary B Gordon; Andrew J Dannenberg; Waun Ki Hong; Carol J Fabian; Caroline C Sigman; Monica M Bertagnolli; Steven P Stratton; Stephen Lam; William G Nelson; Frank L Meyskens; David S Alberts; Michele Follen; Anil K Rustgi; Vali Papadimitrakopoulou; Peter T Scardino; Adi F Gazdar; Lee W Wattenberg; Michael B Sporn; Wael A Sakr; Scott M Lippman; Daniel D Von Hoff
Journal:  Clin Cancer Res       Date:  2002-02       Impact factor: 12.531

2.  The effect of fecal occult-blood screening on the incidence of colorectal cancer.

Authors:  J S Mandel; T R Church; J H Bond; F Ederer; M S Geisser; S J Mongin; D C Snover; L M Schuman
Journal:  N Engl J Med       Date:  2000-11-30       Impact factor: 91.245

Review 3.  ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes.

Authors:  Sapna Syngal; Randall E Brand; James M Church; Francis M Giardiello; Heather L Hampel; Randall W Burt
Journal:  Am J Gastroenterol       Date:  2015-02-03       Impact factor: 10.864

4.  Screening for Lynch syndrome (hereditary nonpolyposis colorectal cancer) among endometrial cancer patients.

Authors:  Heather Hampel; Wendy Frankel; Jenny Panescu; Janet Lockman; Kaisa Sotamaa; Daniel Fix; Ilene Comeras; Jennifer La Jeunesse; Hidewaki Nakagawa; Judith A Westman; Thomas W Prior; Mark Clendenning; Pamela Penzone; Janet Lombardi; Patti Dunn; David E Cohn; Larry Copeland; Lynne Eaton; Jeffrey Fowler; George Lewandowski; Luis Vaccarello; Jeffrey Bell; Gary Reid; Albert de la Chapelle
Journal:  Cancer Res       Date:  2006-08-01       Impact factor: 12.701

5.  [Periodic colonoscopic examinations of persons with a positive family history for colorectal cancer. Work Group 'Hereditary non-polyposis- colon-rectum cancers'].

Authors:  H F Vasen; F M Nagengast; G Griffioen; J H Kleibeuker; F H Menko; B G Taal
Journal:  Ned Tijdschr Geneeskd       Date:  1999-06-05

6.  Body mass index and colon cancer: an evaluation of the modifying effects of estrogen (United States).

Authors:  M L Slattery; Rachel Ballard-Barbash; Sandra Edwards; Bette J Caan; John D Potter
Journal:  Cancer Causes Control       Date:  2003-02       Impact factor: 2.506

7.  New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC.

Authors:  H F Vasen; P Watson; J P Mecklin; H T Lynch
Journal:  Gastroenterology       Date:  1999-06       Impact factor: 22.682

Review 8.  Colorectal cancer in young adults.

Authors:  Jennifer A Inra; Sapna Syngal
Journal:  Dig Dis Sci       Date:  2014-12-06       Impact factor: 3.199

9.  Rates of colon and rectal cancers are increasing in young adults.

Authors:  Jessica B O'Connell; Melinda A Maggard; Jerome H Liu; David A Etzioni; Edward H Livingston; Clifford Y Ko
Journal:  Am Surg       Date:  2003-10       Impact factor: 0.688

10.  Comprehensive molecular characterization of human colon and rectal cancer.

Authors: 
Journal:  Nature       Date:  2012-07-18       Impact factor: 49.962

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  5 in total

1.  Cyclic RGD peptide-modified liposomal drug delivery system for targeted oral apatinib administration: enhanced cellular uptake and improved therapeutic effects.

Authors:  Zhiwang Song; Yun Lin; Xia Zhang; Chan Feng; Yonglin Lu; Yong Gao; Chunyan Dong
Journal:  Int J Nanomedicine       Date:  2017-03-10

Review 2.  Young Adult Cancer: Influence of the Obesity Pandemic.

Authors:  Nathan A Berger
Journal:  Obesity (Silver Spring)       Date:  2018-04       Impact factor: 5.002

3.  TNNT2 as a potential biomarker for the progression and prognosis of colorectal cancer.

Authors:  Li Jing; Li Feng; Zhiguo Zhou; Shuai Shi; Ruoying Deng; Zhicong Wang; Yi Zhang; Zhixue Ren; Yibing Liu
Journal:  Oncol Rep       Date:  2020-06-09       Impact factor: 3.906

4.  Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway.

Authors:  Xia Tian; Meng Liu; Xiaodong Huang; Qingxi Zhu; Weijie Liu; Wei Chen; Yanli Zou; Yishan Cai; Shasha Huang; Aifang Chen; Ting Zhan; Min Huang; Xiaoli Chen; Zheng Han; Jie Tan
Journal:  Onco Targets Ther       Date:  2020-06-11       Impact factor: 4.147

5.  Cold Snare Polypectomy in Patients Taking Dual Antiplatelet Therapy: A Randomized Trial of Discontinuation of Thienopyridines.

Authors:  Dae Won; Joon Sung Kim; Jeong-Seon Ji; Byung-Wook Kim; Hwang Choi
Journal:  Clin Transl Gastroenterol       Date:  2019-10       Impact factor: 4.488

  5 in total

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