| Literature DB >> 27274165 |
Shih-Yu Huang1, Yi-Ann Chen2, Shih-Ann Chen3, Yi-Jen Chen4, Yung-Kuo Lin5.
Abstract
Atrial fibrillation (AF) is the most common cardiac arrhythmia. Chronic kidney disease (CKD) is associated with a high prevalence of AF, and uremic toxins are an important risk factor for cardiovascular diseases associated with CKD. Uremic toxins can produce pro-fibrotic, pro-hypertrophic, and pro-inflammatory effects on cardiac tissues and enhance oxidative stress or neurohormonal phenomena of cardiovascular injury, which are recognized as arrhythmogenic factors of AF. This article reviews the clinical, molecular, and electrophysiological data of uremic toxins in CKD considered to induce AF through multiple mechanisms on structural and electrical remodeling of the cardiovascular system.Entities:
Keywords: Atrial fibrillation; Inflammation; Oxidative stress; Uremic toxins
Year: 2016 PMID: 27274165 PMCID: PMC4884752 DOI: 10.6515/acs20151116a
Source DB: PubMed Journal: Acta Cardiol Sin ISSN: 1011-6842 Impact factor: 2.672