Radovan Pilka1, Radim Marek2, Tomas Adam3, Milan Kudela2, Dana Ondrová2, David Neubert2, Jozef Hambálek2, Martin Maděrka2, Dagmar Solichová4, Lenka Kujovská Krčmová4, Bohuslav Melichar5. 1. Department of Obstetrics and Gynecology, Medical Faculty Palacký University and Faculty Hospital, Olomouc, Czech Republic radovan.pilka@fnol.cz. 2. Department of Obstetrics and Gynecology, Medical Faculty Palacký University and Faculty Hospital, Olomouc, Czech Republic. 3. Department of Laboratory Biochemistry, Medical Faculty Palacký University and Faculty Hospital, Olomouc, Czech Republic. 4. Third Department of Medicine-Gerontology and Metabolic Care, University Hospital, Hradec Králové, Czech Republic. 5. Department of Oncology, Medical Faculty Palacký University and Faculty Hospital, Olomouc, Czech Republic.
Abstract
AIM: To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. MATERIALS AND METHODS: A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively. RESULTS: The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups. CONCLUSION: The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma. Copyright
AIM: To study inflammatory response and nutritional biomarkers in operated endometrial cancer (EC) patients. MATERIALS AND METHODS: A total 109 consecutive EC patients undergoing open laparotomy (LT), laparoscopic (LS) or robot-assisted surgery (RS) were studied. Twenty four patients served as controls. Pre- and postoperative levels of inflammatory and nutritional biomarkers were analyzed prospectively. RESULTS: The estimated blood loss was significantly lower in RS compared to all other groups. C-reactive protein (CRP) and interleukin-6 (IL-6) correlated with each other and exhibited positive correlation with age, body-mass index (BMI), leukocyte count, platelet count, kynurenine, kynurenine/tryptophan ratio and urinary neopterin and a negative correlation with vitamin D and retinol. Hemoglobin, retinol, alpha-tocopherol, vitamin D and citrulline concentrations decreased and inflammatory biomarkers increased after surgery to a different extent in LT, LS, RS and control groups. CONCLUSION: The present data demonstrate a differential response to surgical trauma in patients with endometrial carcinoma. Copyright
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