| Literature DB >> 27270752 |
Rosa Martí-Centelles1, Eva Falomir1, Miguel Carda1, Carla I Nieto2, M Pilar Cornago2, Rosa M Claramunt2.
Abstract
A group of 13 curcuminoid pyrazoles was investigated for their cytotoxicity on three tumoral cell lines (HT-29, MCF-7, and HeLa) and one non-tumoral human cell line (HEK-293). The values obtained were compared with those of curcumin. A subset of selected derivatives was also studied for their ability to downregulate expression of the hTERT and c-Myc genes, which are both involved in telomerase activity.Entities:
Keywords: Curcuminoid pyrazoles; Cytotoxicity; Gene downregulation; Telomerase
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Year: 2016 PMID： 27270752 DOI： 10.1002/ardp.201600067
Source DB: PubMed Journal: Arch Pharm (Weinheim) ISSN： 0365-6233 Impact factor: 3.751