Literature DB >> 27270287

Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature.

Alice L den Hertog1, Sandra Menting2, Richard Pfeltz3, Matthew Warns3, Salman H Siddiqi3, Richard M Anthony1.   

Abstract

For the past decades, an acidic pH has been used to render Mycobacterium tuberculosis susceptible to pyrazinamide for in vitro testing. Here, we show that at the standard breakpoint concentration and reduced culture temperatures, pyrazinamide (PZA) is active against tuberculosis (TB) at neutral pH. This finding should help unravel the mechanism of action of PZA and allow drug susceptibility testing (DST) methods to be optimized.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2016        PMID： 27270287      PMCID： PMC4958174          DOI： 10.1128/AAC.00654-16

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Kinetics and inhibition of nicotinamidase from Mycobacterium tuberculosis.

Authors:  Derrick R Seiner; Subray S Hegde; John S Blanchard
Journal:  Biochemistry       Date:  2010-11-09       Impact factor: 3.162

2.  Activation of pyrazinamide and nicotinamide in acidic environments in vitro.

Authors:  W McDERMOTT; R TOMPSETT
Journal:  Am Rev Tuberc       Date:  1954-10

3.  Proficiency of drug susceptibility testing of Mycobacterium tuberculosis against pyrazinamide: the Swedish experience.

Authors:  S Hoffner; K Angeby; E Sturegård; B Jönsson; A Johansson; M Sellin; J Werngren
Journal:  Int J Tuberc Lung Dis       Date:  2013-11       Impact factor: 2.373

4.  Pyrazinoic acid decreases the proton motive force, respiratory ATP synthesis activity, and cellular ATP levels.

Authors:  Ping Lu; Anna C Haagsma; Hoang Pham; Janneke J Maaskant; Selena Mol; Holger Lill; Dirk Bald
Journal:  Antimicrob Agents Chemother       Date:  2011-08-29       Impact factor: 5.191

Review 5.  Pyrazinamide: the importance of uncovering the mechanisms of action in mycobacteria.

Authors:  Matthias Stehr; Ayssar A Elamin; Mahavir Singh
Journal:  Expert Rev Anti Infect Ther       Date:  2015-03-06       Impact factor: 5.091

6.  Slow growth of Mycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources.

Authors:  Jacob J Baker; Benjamin K Johnson; Robert B Abramovitch
Journal:  Mol Microbiol       Date:  2014-07-13       Impact factor: 3.501

7.  Aspartate decarboxylase (PanD) as a new target of pyrazinamide in Mycobacterium tuberculosis.

Authors:  Wanliang Shi; Jiazhen Chen; Jie Feng; Peng Cui; Shuo Zhang; Xinhua Weng; Wenhong Zhang; Ying Zhang
Journal:  Emerg Microbes Infect       Date:  2014-08-13       Impact factor: 7.163

8.  Evolution and transmission of drug-resistant tuberculosis in a Russian population.

Authors:  Nicola Casali; Vladyslav Nikolayevskyy; Yanina Balabanova; Simon R Harris; Olga Ignatyeva; Irina Kontsevaya; Jukka Corander; Josephine Bryant; Julian Parkhill; Sergey Nejentsev; Rolf D Horstmann; Timothy Brown; Francis Drobniewski
Journal:  Nat Genet       Date:  2014-01-26       Impact factor: 38.330

9.  Biochemical characterization of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv and inhibition of its activity by pyrazinamide.

Authors:  Hyun Kim; Keigo Shibayama; Emiko Rimbara; Shigetarou Mori
Journal:  PLoS One       Date:  2014-06-20       Impact factor: 3.240

10.  Evaluation of a microcolony growth monitoring method for the rapid determination of ethambutol resistance in Mycobacterium tuberculosis.

Authors:  Alice L den Hertog; Sandra Menting; Ernst T Smienk; Jim Werngren; Sven Hoffner; Richard M Anthony
Journal:  BMC Infect Dis       Date:  2014-07-10       Impact factor: 3.090
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  9 in total

Review 1.  Pharmacological and Molecular Mechanisms Behind the Sterilizing Activity of Pyrazinamide.

Authors:  Pooja Gopal; Gerhard Grüber; Véronique Dartois; Thomas Dick
Journal:  Trends Pharmacol Sci       Date:  2019-11-06       Impact factor: 14.819

Review 2.  The Bewildering Antitubercular Action of Pyrazinamide.

Authors:  Elise A Lamont; Nicholas A Dillon; Anthony D Baughn
Journal:  Microbiol Mol Biol Rev       Date:  2020-03-04       Impact factor: 11.056

Review 3.  New Approaches and Therapeutic Options for Mycobacterium tuberculosis in a Dormant State.

Authors:  Santiago Caño-Muñiz; Richard Anthony; Stefan Niemann; Jan-Willem C Alffenaar
Journal:  Clin Microbiol Rev       Date:  2017-11-29       Impact factor: 26.132

4.  Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia.

Authors:  Sarah Sengstake; Indra L Bergval; Anja R Schuitema; Jessica L de Beer; Jody Phelan; Rina de Zwaan; Taane G Clark; Dick van Soolingen; Richard M Anthony
Journal:  BMC Infect Dis       Date:  2017-07-12       Impact factor: 3.090

5.  Spatial relationships of intra-lesion heterogeneity in Mycobacterium tuberculosis microenvironment, replication status, and drug efficacy.

Authors:  Richard C Lavin; Shumin Tan
Journal:  PLoS Pathog       Date:  2022-03-28       Impact factor: 6.823

6.  N-Pyrazinoyl Substituted Amino Acids as Potential Antimycobacterial Agents-The Synthesis and Biological Evaluation of Enantiomers.

Authors:  Martin Juhás; Lucie Kučerová; Ondřej Horáček; Ondřej Janďourek; Vladimír Kubíček; Klára Konečná; Radim Kučera; Pavel Bárta; Jiří Janoušek; Pavla Paterová; Jiří Kuneš; Martin Doležal; Jan Zitko
Journal:  Molecules       Date:  2020-03-27       Impact factor: 4.411

7.  Direct Determination of Pyrazinamide (PZA) Susceptibility by Sputum Microscopic Observation Drug Susceptibility (MODS) Culture at Neutral pH: the MODS-PZA Assay.

Authors:  Roberto Alcántara; Patricia Fuentes; Lisette Marin; Daniela E Kirwan; Robert H Gilman; Mirko Zimic; Patricia Sheen
Journal:  J Clin Microbiol       Date:  2020-04-23       Impact factor: 5.948

Review 8.  Impact of the host environment on the antitubercular action of pyrazinamide.

Authors:  Elise A Lamont; Anthony D Baughn
Journal:  EBioMedicine       Date:  2019-10-25       Impact factor: 8.143

9.  Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.

Authors:  Pierre Santucci; Beren Aylan; Laure Botella; Elliott M Bernard; Claudio Bussi; Enrica Pellegrino; Natalia Athanasiadi; Maximiliano G Gutierrez
Journal:  mBio       Date:  2022-03-24       Impact factor: 7.786
  9 in total

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