| Literature DB >> 27269726 |
Jerry Edward Chipuk1, Mark P Luna-Vargas2.
Abstract
Mechanistic insights into the function of the pro-apoptotic BCL-2 family member BOK have remained elusive. A recent study shows that healthy cells constitutively degrade BOK via the ER-associated degradation and ubiquitin-proteasome pathways; following proteasome inhibition, BOK is stabilized to initiate a unique pro-apoptotic death program.Entities:
Mesh：
Substances：
Year: 2016 PMID： 27269726 DOI： 10.1016/j.cub.2016.04.003
Source DB: PubMed Journal: Curr Biol ISSN： 0960-9822 Impact factor: 10.834