Do Young Kim1, In Su Kim1, Sang Gyu Park1, Hyojeong Kim1, Young Jin Choi1, Young Mi Seol2. 1. Department of Hematology-Oncology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea. 2. Department of Hematology-Oncology, Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea. Electronic address: seol2100@hanmail.net.
Abstract
OBJECTIVE: An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancer patients receiving chemoradiotherapy. METHODS: This study included 104 patients with treatment-naïve head and neck cancer who underwent definitive chemoradiotherapy. An inflammatory marker was measured at baseline and after 1 month of treatment. Univariate and multivariate analyses using Cox proportional hazards model were used to identify predictors of progression-free survival (PFS) and overall survival (OS). RESULTS: A univariate analysis revealed that T,N-stage, the pre- and posttreatment NLRs were significant predictors of progression after the chemoradiotherapy. However, the posttreatment NLR remained an independent predictor of PFS in the multivariate analysis (HR=2.23, 95% CI 1.15-2.321; P=0.001). A high posttreatment NLR was significantly associated with an increased risk of death (HR=1.87, 95% CI 0.89-3.31; P=0.037). CONCLUSION: A high posttreatment NLR is associated with poor prognostic factor. An early reduction in the NLR after treatment may indicate survival improvement in the patients.
OBJECTIVE: An inflammatory-immunological marker, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), was evaluated as a predictive marker of advanced head and neck cancerpatients receiving chemoradiotherapy. METHODS: This study included 104 patients with treatment-naïve head and neck cancer who underwent definitive chemoradiotherapy. An inflammatory marker was measured at baseline and after 1 month of treatment. Univariate and multivariate analyses using Cox proportional hazards model were used to identify predictors of progression-free survival (PFS) and overall survival (OS). RESULTS: A univariate analysis revealed that T,N-stage, the pre- and posttreatment NLRs were significant predictors of progression after the chemoradiotherapy. However, the posttreatment NLR remained an independent predictor of PFS in the multivariate analysis (HR=2.23, 95% CI 1.15-2.321; P=0.001). A high posttreatment NLR was significantly associated with an increased risk of death (HR=1.87, 95% CI 0.89-3.31; P=0.037). CONCLUSION: A high posttreatment NLR is associated with poor prognostic factor. An early reduction in the NLR after treatment may indicate survival improvement in the patients.
Authors: Alexander J Lin; Margery Gang; Yuan James Rao; Jian Campian; Mackenzie Daly; Hiram Gay; Peter Oppelt; Ryan S Jackson; Jason Rich; Randal Paniello; Jose Zevallos; Dennis Hallahan; Douglas Adkins; Wade Thorstad Journal: JAMA Otolaryngol Head Neck Surg Date: 2019-05-01 Impact factor: 6.223
Authors: Whitney A Sumner; William A Stokes; Ayman Oweida; Kiersten L Berggren; Jessica D McDermott; David Raben; Diana Abbott; Bernard Jones; Gregory Gan; Sana D Karam Journal: J Transl Med Date: 2017-08-02 Impact factor: 5.531