Literature DB >> 2726774

Effect of glycyl-L-glutamine on the rate of regeneration of acetylcholinesterase in the rat gastrocnemius muscle after diisopropyl phosphorofluoridate administration.

G B Koelle1, M S Han.   

Abstract

Rats were given glycyl-L-glutamine (Gly-Gln) by intraaortic infusion with Alzet osmotic pumps during the 48-hr period following the intraaortic administration of diisopropyl phosphorofluoridate (DFP) (10 mumol/kg). The infusion of 1.2 mumol of Gly-Gln per 24 hr resulted in a significant increase in the acetylcholinesterase (AcChoEase; acetylcholine acetylhydrolase, EC 3.1.1.7) activity of the gastrocnemius muscles over that of rats that received DFP only. At a total dose of 3.6 mumol per 24 hr, a diminished result was obtained; at 0.36 mumol per 24 hr, no effect was detectable. These findings, together with earlier ones, suggest that the neurotrophic effect of Gly-Gln or a similar endogenous factor on AcChoEase synthesis is a general phenomenon at sites of cholinergic transmission.

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Year:  1989        PMID： 2726774      PMCID： PMC287446          DOI： 10.1073/pnas.86.11.4331

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  8 in total

1.  A new and rapid colorimetric determination of acetylcholinesterase activity.

Authors:  G L ELLMAN; K D COURTNEY; V ANDRES; R M FEATHER-STONE
Journal:  Biochem Pharmacol       Date:  1961-07       Impact factor: 5.858

Review 2.  Thyroid hormone receptors and responses.

Authors:  J D Baxter; N L Eberhardt; J W Apriletti; L K Johnson; R D Ivarie; B S Schachter; J A Morris; P H Seeburg; H M Goodman; K R Latham; J R Polansky; J A Martial
Journal:  Recent Prog Horm Res       Date:  1979

3.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

Review 4.  Enhancement of acetylcholinesterase synthesis by glycyl-L-glutamine: an example of a small peptide that regulates differential transcription?

Authors:  G B Koelle
Journal:  Trends Pharmacol Sci       Date:  1988-09       Impact factor: 14.819

5.  Maintenance by glycyl-L-glutamine in vivo of molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.

Authors:  G B Koelle; K A Skau; N S Thampi; D M Hymel; M S Han
Journal:  Proc Natl Acad Sci U S A       Date:  1988-08       Impact factor: 11.205

6.  Effects of glycyl-L-glutamine in vitro on the molecular forms of acetylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.

Authors:  G B Koelle; J Massoulié; D Eugène; M A Melone
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

7.  Direct neurotrophic action of glycyl-L-glutamine in the maintenance of acetylcholinesterase and butyrylcholinesterase in the preganglionically denervated superior cervical ganglion of the cat.

Authors:  G B Koelle; U J Sanville; N S Thampi
Journal:  Proc Natl Acad Sci U S A       Date:  1987-10       Impact factor: 11.205

8.  Regeneration of cholinesterases in the stellate and normal and denervated superior cervical ganglion of the cat following inactivation by sarin.

Authors:  G B Koelle; G A Ruch; K K Rickard; U J Sanville
Journal:  J Neurochem       Date:  1982-06       Impact factor: 5.372
  8 in total
  4 in total

1.  Effects of glycyl-L-glutamine and methylprednisolone on maintenance of acetylcholinesterase of transected rat sciatic nerves.

Authors:  G B Koelle; M S Han
Journal:  Proc Natl Acad Sci U S A       Date:  1990-12       Impact factor: 11.205

2.  Glycyl-L-glutamine opposes the fall in choline acetyltransferase in the denervated superior cervical ganglion of the cat.

Authors:  G B Koelle; J J O'Neill; N S Thampi; M S Han; R Caccese
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

3.  Regeneration of acetylcholinesterase in clonal neuroblastoma-glioma hybrid NG108-15 cells after soman inhibition: effect of glycyl-L-glutamine.

Authors:  J J Yourick; P A Eklo; M P McCluskey; R Ray
Journal:  Cell Biol Toxicol       Date:  1991-07       Impact factor: 6.691

4.  Testosterone control of endplate and non-endplate acetylcholinesterase in the rat levator ani muscle.

Authors:  R O Godinho; C Souccar; A J Lapa
Journal:  Neurochem Res       Date:  1994-06       Impact factor: 3.996
  4 in total

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