Literature DB >> 272660

Evidence that tumor antigens enhance tumor growth in vivo by interacting with a radiosensitive (suppressor?) cell population.

K E Hellström, I Hellström.   

Abstract

The growth of a small number of cells from each of two chemically induced BALB/c sarcomas was enhanced when x-irradiated (15,000 rads) cells of the same sarcoma were mixed with the tumor inoculum. This enhancement did not occur if the recipients had been given a total body x-irradiation of 450 rads. Tumor neutralization (Winn) tests showed that tumor cells irradiated in vitro enhanced tumor growth only in the presence of radiosensitive cells present in the spleens of both nonimmune and tumor-bearing mice. On the basis of these findings we postulate that tumor antigen blocks effective tumor immunity by a mechanism that involves a suppressor cell population.

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Year:  1978        PMID： 272660      PMCID： PMC411264          DOI： 10.1073/pnas.75.1.436

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  26 in total

1.  Effect of lethally damaged tumor cells upon the development of admixed viable cells.

Authors:  L REVESZ
Journal:  J Natl Cancer Inst       Date:  1958-06       Impact factor: 13.506

2.  Cell-mediated destruction of Rous sarcomas in Japanese quails.

Authors:  M Hayami; I Hellström; K E Hellström; K Yamanouchi
Journal:  Int J Cancer       Date:  1972-11       Impact factor: 7.396

3.  Blocking of lymphocyte-mediated cytotoxicity for rat hepatoma cells by tumour-specific antigen-antibody complexes.

Authors:  R W Baldwin; M R Price; R A Robins
Journal:  Nat New Biol       Date:  1972-08-09

4.  The effect of immunoregulatory globulin (IRA) upon lymphocytes in vitro.

Authors:  S R Cooperband; A M Badger; R C Davis; K Schmid; J A Mannick
Journal:  J Immunol       Date:  1972-07       Impact factor: 5.422

Review 5.  Specific blocking factors--are they important?

Authors:  K E Hellström; I Hellström; J T Nepom
Journal:  Biochim Biophys Acta       Date:  1977-12-23

6.  Immunosuppressive factor(s) extracted from lymphoid cells of nonresponder mice primed with L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT).

Authors:  J A Kapp; C W Pierce; F De la Croix; B Benacerraf
Journal:  J Immunol       Date:  1976-02       Impact factor: 5.422

7.  Discussion paper: specific paralysis of the antitumor cellular immune response produced by growing tumors studied with a radioisotope footpad assay.

Authors:  M S Paranjpe; C W Boone; N Takeichi
Journal:  Ann N Y Acad Sci       Date:  1976       Impact factor: 5.691

8.  Suggestive evidence that the "blocking antibodies" of tumor-bearing individuals may be antigen--antibody complexes.

Authors:  H O Sjögren; I Hellström; S C Bansal; K E Hellström
Journal:  Proc Natl Acad Sci U S A       Date:  1971-06       Impact factor: 11.205

9.  Regulation of the immune response to tumor antigens. III. Characterization of thymic suppressor factor(s) produced by tumor-bearing hosts.

Authors:  M I Greene; S Fujimoto; A H Sehon
Journal:  J Immunol       Date:  1977-08       Impact factor: 5.422

10.  Antigen-specific purification of blocking factors from sera of mice with chemically induced tumors.

Authors:  J T Nepom; I Hellström; K E Hellström
Journal:  Proc Natl Acad Sci U S A       Date:  1977-10       Impact factor: 11.205
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  8 in total

1.  Tumor size, leukocyte adherence inhibition and serum levels of tumor antigen in dogs with the canine transmissible venereal sarcoma.

Authors:  T J Yang; T J Palker; M W Harding
Journal:  Cancer Immunol Immunother       Date:  1991       Impact factor: 6.968

2.  The effects of cyclophosphamide and irradiation singly and in combination upon SaI growth in A/J mice.

Authors:  R E Anderson; W L Williams; S Tokuda
Journal:  Am J Pathol       Date:  1987-05       Impact factor: 4.307

Review 3.  Suppressor mechanisms in tumor immunity.

Authors:  G T Nepom; I Hellström; K E Hellström
Journal:  Experientia       Date:  1983-03-15

4.  Amplifying TLR-MyD88 signals within tumor-specific T cells enhances antitumor activity to suboptimal levels of weakly immunogenic tumor antigens.

Authors:  Degui Geng; Liqin Zheng; Ratika Srivastava; Cruz Velasco-Gonzalez; Adam Riker; Svetomir N Markovic; Eduardo Davila
Journal:  Cancer Res       Date:  2010-08-31       Impact factor: 12.701

5.  Radiation-induced augmentation of the response of A/J mice to SaI tumor cells.

Authors:  R E Anderson; S Tokuda; W L Williams; N L Warner
Journal:  Am J Pathol       Date:  1982-07       Impact factor: 4.307

6.  Tumor-enhancing suppressor activator T cells in spleens and thymuses of tumor immune mice.

Authors:  I Hellström; K E Hellström; I D Bernstein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

7.  In vivo detection and partial characterization of effector and suppressor cell populations in spleens of mice with large metastatic fibrosarcomas.

Authors:  L A Dent; J J Finlay-Jones
Journal:  Br J Cancer       Date:  1985-04       Impact factor: 7.640

8.  Enhancement of growth of a radiation-induced lymphoma by T cells from normal mice.

Authors:  A Gabizon; N Trainin
Journal:  Br J Cancer       Date:  1980-10       Impact factor: 7.640
  8 in total

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