Z Hasan1, R C Dwivedi2, D A Gunaratne3, S A Virk4, C E Palme3, F Riffat3. 1. Department of Otolaryngology-Head & Neck Surgery, Westmead Hospital, Cnr Darcy & Hawkesbury Road, Westmead, NSW, 2145, Australia. Electronic address: zubairhasan_112@hotmail.com. 2. Addenbrooke's Hospital, Cambridge University Teaching Hospital NHS Trust, Royal Marsden Hospital, London, UK. 3. Department of Otolaryngology-Head & Neck Surgery, Westmead Hospital, Cnr Darcy & Hawkesbury Road, Westmead, NSW, 2145, Australia. 4. University of New South Wales, Randwick, NSW, 2052, Australia.
Abstract
BACKGROUND AND OBJECTIVES: Management paradigms in laryngeal cancer have shifted to "organ preservation" chemoradiotherapy protocols. In the event of treatment failure, salvage total laryngectomy remains the only curative treatment option. However a comprehensive review of the complications of this procedure has not been reported. METHODS: A systematic review of the literature was performed using keywords "salvage laryngectomy" to retrieve relevant publications between January 2000 and August 2015. RESULTS: Of the 407 articles retrieved from the literature search, 50 studies encompassing 3292 patients were included. Forty-nine studies reported pharyngocutaneous fistula which occurred in 859 patients (pooled incidence 28.9%; 95% confidence intervals 25.5-32.5%). Twenty-four studies reported complications in addition to PCF and these included wound complications (infection, dehiscence and necrosis), dysphagia, bleeding, and pharyngeal and stomal stenosis. CONCLUSIONS: Overall complication rate was 67.5%, Pharyngocutaneous fistula was the commonest complication with a pooled incidence of 28.9%. Crown
BACKGROUND AND OBJECTIVES: Management paradigms in laryngeal cancer have shifted to "organ preservation" chemoradiotherapy protocols. In the event of treatment failure, salvage total laryngectomy remains the only curative treatment option. However a comprehensive review of the complications of this procedure has not been reported. METHODS: A systematic review of the literature was performed using keywords "salvage laryngectomy" to retrieve relevant publications between January 2000 and August 2015. RESULTS: Of the 407 articles retrieved from the literature search, 50 studies encompassing 3292 patients were included. Forty-nine studies reported pharyngocutaneous fistula which occurred in 859 patients (pooled incidence 28.9%; 95% confidence intervals 25.5-32.5%). Twenty-four studies reported complications in addition to PCF and these included wound complications (infection, dehiscence and necrosis), dysphagia, bleeding, and pharyngeal and stomal stenosis. CONCLUSIONS: Overall complication rate was 67.5%, Pharyngocutaneous fistula was the commonest complication with a pooled incidence of 28.9%. Crown
Authors: Janice L Farlow; Andrew C Birkeland; Anna Hardenbergh; Teresa Lyden; J Chad Brenner; Andrew G Shuman; Steven B Chinn; Chaz L Stucken; Kelly M Malloy; Jeffrey S Moyer; Keith A Casper; Mark E P Prince; Carol R Bradford; Gregory T Wolf; Douglas B Chepeha; Andrew J Rosko; Matthew E Spector Journal: Eur Arch Otorhinolaryngol Date: 2020-01-27 Impact factor: 2.503
Authors: Andrew J Rosko; Andrew C Birkeland; Emily Bellile; Kevin J Kovatch; Ashley L Miller; Craig C Jaffe; Andrew G Shuman; Steven B Chinn; Chaz L Stucken; Kelly M Malloy; Jeffrey S Moyer; Keith A Casper; Mark E P Prince; Carol R Bradford; Gregory T Wolf; Douglas B Chepeha; Matthew E Spector Journal: Ann Surg Oncol Date: 2017-12-20 Impact factor: 5.344
Authors: Erin J Partington; Lindsay S Moore; Russel Kahmke; Jason M Warram; William Carroll; Eben L Rosenthal; Benjamin J Greene Journal: JAMA Otolaryngol Head Neck Surg Date: 2017-08-01 Impact factor: 6.223
Authors: Liset Lansaat; Vincent van der Noort; Simone E Bernard; Simone E J Eerenstein; Boudewijn E C Plaat; Ton A P M Langeveld; Martin Lacko; Frans J M Hilgers; Remco de Bree; Robert P Takes; Michiel W M van den Brekel Journal: Eur Arch Otorhinolaryngol Date: 2018-01-16 Impact factor: 2.503