E Premi1, A Pilotto2, V Garibotto3, B Bigni4, R Turrone4, A Alberici4, E Cottini4, L Poli4, M Bianchi4, A Formenti4, M Cosseddu4, S Gazzina4, M Magoni5, M Bertoli6, B Paghera6, B Borroni4, A Padovani4. 1. Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Stroke Unit, Azienda Ospedaliera "Spedali Civili", Spedali Civili Hospital, Brescia, Italy. Electronic address: zedtower@gmail.com. 2. Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy; Department of Neurodegeneration and Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany. 3. Department of Medical Imaging, Geneva University Hospital, Geneva, Switzerland. 4. Neurology Unit, Department of Clinical and Experimental Sciences, University of Brescia, Italy. 5. Stroke Unit, Azienda Ospedaliera "Spedali Civili", Spedali Civili Hospital, Brescia, Italy. 6. Nuclear Medicine Unit, Azienda Azienda Ospedaliera "Spedali Civili", Spedali Civili Hospital, Brescia, Italy.
Abstract
BACKGROUND: Impulse Control Disorder symptoms (ICD) in Parkinson's disease (PD) has been recently associated by magnetic Resonance imaging with impaired cortico-striatal connectivity, especially between left putamen and frontal associative areas. METHODS: 84 patients entered the study (21 PD-ICD+ and 64 PD-ICD-) and underwent DATSCAN imaging. The striatal tracer uptake was evaluated using BRASS software (Hermes, Sweden). The whole-brain analysis was performed with Statistical Parametric Mapping (SPM). RESULTS: PD-ICD+ showed a significant reduction of left putaminal and left inferior frontal gyrus tracer uptake compared to PD-ICD-. Functional covariance analysis using left putamen as the seed point showed that, in contrast to ICD-patients, ICD+ patients had no functional covariance with contralateral basal ganglia and ipsilateral cingulate cortex, as index of an impaired inter- and intra-hemispheric dopamine binding in PD-ICD+. DISCUSSION: the results support and expand the concept of a functional disconnection syndrome linked to ICD symptoms in PD patients through an asymmetric molecular frontostriatal network breakdown with left basal ganglia as central hub.
BACKGROUND: Impulse Control Disorder symptoms (ICD) in Parkinson's disease (PD) has been recently associated by magnetic Resonance imaging with impaired cortico-striatal connectivity, especially between left putamen and frontal associative areas. METHODS: 84 patients entered the study (21 PD-ICD+ and 64 PD-ICD-) and underwent DATSCAN imaging. The striatal tracer uptake was evaluated using BRASS software (Hermes, Sweden). The whole-brain analysis was performed with Statistical Parametric Mapping (SPM). RESULTS: PD-ICD+ showed a significant reduction of left putaminal and left inferior frontal gyrus tracer uptake compared to PD-ICD-. Functional covariance analysis using left putamen as the seed point showed that, in contrast to ICD-patients, ICD+ patients had no functional covariance with contralateral basal ganglia and ipsilateral cingulate cortex, as index of an impaired inter- and intra-hemispheric dopamine binding in PD-ICD+. DISCUSSION: the results support and expand the concept of a functional disconnection syndrome linked to ICD symptoms in PD patients through an asymmetric molecular frontostriatal network breakdown with left basal ganglia as central hub.
Authors: I Navalpotro-Gomez; R Dacosta-Aguayo; F Molinet-Dronda; A Martin-Bastida; A Botas-Peñin; H Jimenez-Urbieta; M Delgado-Alvarado; B Gago; A Quiroga-Varela; Maria C Rodriguez-Oroz Journal: Eur J Nucl Med Mol Imaging Date: 2019-07-04 Impact factor: 9.236
Authors: Enrico Premi; V D Calhoun; V Garibotto; R Turrone; A Alberici; E Cottini; A Pilotto; S Gazzina; M Magoni; B Paghera; B Borroni; A Padovani Journal: Mol Imaging Biol Date: 2017-10 Impact factor: 3.488