| Literature DB >> 27264075 |
Xinhua Xiao1, Han Li1, Xiaoyan Qi1, Yadi Wang1, Canxin Xu2, Gexin Liu1, Gebo Wen1, Jianghua Liu3.
Abstract
Zinc alpha2 glycoprotein (ZAG) plays an important role in stimulating fat mobilization and lipolysis in adipose tissue, but its role in hepatic lipid metabolism remains unclear. Palmitic acid (PA) was used to stimulate HepG2 cells with ZAG overexpression or ZAG knock down (shRNA). Overexpression of ZAG significantly inhibited lipogenesis, promoted lipolysis and fatty acid β-oxidation, and attenuated PA-induced intracellular fat accumulation. Moreover, ZAG overexpression dramatically stimulated adiponectin expression in HepG2 cells. In contrast, knockdown of ZAG notably inhibited fatty acid β-oxidation, increased lipogenesis and lipid accumulation. Collectively, these data suggest that ZAG has the potential to alleviate hepatosteatosis, making it a promising therapeutic target for fatty liver. Copyright ÂEntities:
Keywords: Adiponectin; Fatty acid oxidation; Lipogenesis; Non-alcoholic fatty liver disease; Nuclear receptors; Triglycerides
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Year: 2016 PMID： 27264075 DOI： 10.1016/j.mce.2016.06.003
Source DB: PubMed Journal: Mol Cell Endocrinol ISSN： 0303-7207 Impact factor: 4.102