Jing Zhang1, Yihao Guo2, Xiangliang Tan1, Zeyu Zheng1, Mengqi He1, Jun Xu3, Yingjie Mei4, Jiajun Zhang1, Xixi Zhao1, Chunhong Wang1, Yanqiu Feng2, Queenie Chan5, Yuankui Wu1, Yikai Xu6. 1. Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. 2. Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou, China. 3. Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou, China. 4. Philips Healthcare, Guangzhou 18F, Tower B, CIC No.33 Zhongshan san Road, YueXiu District, Guangzhou, China. 5. Philips Healthcare, Science Park East Avenue, Hong Kong Science Park, New Territories, Hong Kong. 6. Department of Medical Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China. Electronic address: yikai.xu@163.com.
Abstract
PURPOSE: To explore the usefulness of intravoxel incoherent motion (IVIM) to evaluate the hepatic functional reserve as expressed by the model for Child-Pugh class. MATERIALS AND METHODS: IVIM diffusion-weighted imaging (DWI) using 10 different b values were performed on a Philips 3.0T MR scanner in 70 patients with liver cirrhosis and 60 healthy volunteers as the control group. Patients with liver cirrhosis were subdivided into three groups: Child-Pugh class A: 29 cases; Child-Pugh class B: 19 cases; Child-Pugh class C: 22 cases. Pure molecular diffusion (D), pseudo-diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) values were calculated, and used to determine liver function, as indicated by the Child-Pugh class. RESULTS: The ICC values of D, D*, f and ADC between two radiologists were 0.997, 0.986, 0.985 and 0.995, respectively. D*, f and ADC values of liver cirrhosis group were significantly lower than control group (P<0.001, P=0.016, P=0.042, respectively). D*, f and ADC values significantly decreased with increasing Child-Pugh scores (p<0.05). Child-Pugh scores were inversely correlated with D* and f values (r=-0.423, r=-0.620, respectively). The areas under the curve (AUCs) of D* and f for evaluating liver function were 0.67-0.90 and 0.78-0.89, respectively. CONCLUSION: IVIM DWI may be a useful image-based method for assessing liver function.
PURPOSE: To explore the usefulness of intravoxel incoherent motion (IVIM) to evaluate the hepatic functional reserve as expressed by the model for Child-Pugh class. MATERIALS AND METHODS: IVIM diffusion-weighted imaging (DWI) using 10 different b values were performed on a Philips 3.0T MR scanner in 70 patients with liver cirrhosis and 60 healthy volunteers as the control group. Patients with liver cirrhosis were subdivided into three groups: Child-Pugh class A: 29 cases; Child-Pugh class B: 19 cases; Child-Pugh class C: 22 cases. Pure molecular diffusion (D), pseudo-diffusion (D*), perfusion fraction (f) and apparent diffusion coefficient (ADC) values were calculated, and used to determine liver function, as indicated by the Child-Pugh class. RESULTS: The ICC values of D, D*, f and ADC between two radiologists were 0.997, 0.986, 0.985 and 0.995, respectively. D*, f and ADC values of liver cirrhosis group were significantly lower than control group (P<0.001, P=0.016, P=0.042, respectively). D*, f and ADC values significantly decreased with increasing Child-Pugh scores (p<0.05). Child-Pugh scores were inversely correlated with D* and f values (r=-0.423, r=-0.620, respectively). The areas under the curve (AUCs) of D* and f for evaluating liver function were 0.67-0.90 and 0.78-0.89, respectively. CONCLUSION: IVIM DWI may be a useful image-based method for assessing liver function.
Authors: Narine Mesropyan; Patrick A Kupczyk; Leona Dold; Michael Praktiknjo; Johannes Chang; Alexander Isaak; Christoph Endler; Dmitrij Kravchenko; Leon M Bischoff; Alois M Sprinkart; Claus C Pieper; Daniel Kuetting; Christian Jansen; Ulrike I Attenberger; Julian A Luetkens Journal: Sci Rep Date: 2022-06-08 Impact factor: 4.996