Zhuoxian Zhao1, Olaoluwa O Okusaga2, Joao Quevedo3, Jair C Soares4, Antonio L Teixeira5. 1. Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA. Electronic address: zxzhao1986@gmail.com. 2. University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA. 3. Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA; Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina (UNESC), Criciúma, SC, Brazil. 4. University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA; Center of Excellence on Mood Disorders, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; Neuroscience Graduate Program, The University of Texas Graduate School of Biomedical Sciences at Houston, Houston, TX, USA. 5. Translational Psychiatry Program, Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX, USA; University of Texas Harris County Psychiatric Center, 2800 South MacGregor Way, Houston, TX 77021, USA. Electronic address: antonio.l.teixeira@uth.tmc.edu.
Abstract
BACKGROUND: Several epidemiological studies have found that the prevalence of bipolar disorder (BD) is significantly higher in obese population than non-obese population. However, no meta-analysis has been published to quantitatively summarize the related literature. METHODS: In this study, we conducted a meta-analysis to explore the association between obesity and BD by combining 9 cross-sectional studies with a total of 12,259 BD cases and 615,490 non-BD controls. The meta-analysis was performed using the effect estimates and 95% confidence intervals (CIs) to calculate the pooled odds ratio (OR), while the heterogeneity was assessed using I(2) and Q statistic. RESULTS: Our meta-analysis suggests that obesity is associated with increased prevalence of BD by a random-effect model (OR=1.77, 95% CI: 1.40-2.23; Q=44.62, P<0.001, I(2)=82.1%). LIMITATION: Without prospective studies, we cannot determine whether obesity increased the risk of developing BD or vice-versa. CONCLUSION: Obesity is positively associated with BD.
BACKGROUND: Several epidemiological studies have found that the prevalence of bipolar disorder (BD) is significantly higher in obese population than non-obese population. However, no meta-analysis has been published to quantitatively summarize the related literature. METHODS: In this study, we conducted a meta-analysis to explore the association between obesity and BD by combining 9 cross-sectional studies with a total of 12,259 BD cases and 615,490 non-BD controls. The meta-analysis was performed using the effect estimates and 95% confidence intervals (CIs) to calculate the pooled odds ratio (OR), while the heterogeneity was assessed using I(2) and Q statistic. RESULTS: Our meta-analysis suggests that obesity is associated with increased prevalence of BD by a random-effect model (OR=1.77, 95% CI: 1.40-2.23; Q=44.62, P<0.001, I(2)=82.1%). LIMITATION: Without prospective studies, we cannot determine whether obesity increased the risk of developing BD or vice-versa. CONCLUSION:Obesity is positively associated with BD.
Authors: Gabriela D Colpo; Marion Leboyer; Robert Dantzer; Mahdukar H Trivedi; Antonio L Teixeira Journal: Expert Rev Neurother Date: 2017-11-27 Impact factor: 4.618
Authors: Benjamin I Goldstein; Bernhard T Baune; David J Bond; Pao-Huan Chen; Lisa Eyler; Andrea Fagiolini; Fabiano Gomes; Tomas Hajek; Jessica Hatch; Susan L McElroy; Roger S McIntyre; Miguel Prieto; Louisa G Sylvia; Shang-Ying Tsai; Andrew Kcomt; Jess G Fiedorowicz Journal: Bipolar Disord Date: 2020-06-08 Impact factor: 6.744
Authors: Jonathan M Meyer; Daisy S Ng-Mak; Chien-Chia Chuang; Krithika Rajagopalan; Antony Loebel Journal: Ann Gen Psychiatry Date: 2017-10-17 Impact factor: 3.455
Authors: Fang Yang; Izabela G Barbosa; Erica L Vieira; Moises E Bauer; Natalia P Rocha; Antonio L Teixeira Journal: Transl Neurosci Date: 2018-03-23 Impact factor: 1.757
Authors: Sarah Kittel-Schneider; Daniel Bury; Karolina Leopold; Sara Haack; Michael Bauer; Steffi Pfeiffer; Cathrin Sauer; Andrea Pfennig; Henry Völzke; Hans-Jörgen Grabe; Andreas Reif Journal: Front Psychiatry Date: 2020-04-22 Impact factor: 4.157