| Literature DB >> 27261916 |
Yifan Zheng1, Michael T Jaklitsch1, Raphael Bueno2.
Abstract
Locally advanced (stage IIIA) non-small cell lung cancer (NSCLC) is confined to the chest, but requires more than surgery to maximize cure. Therapy given preoperatively is termed neoadjuvant, whereas postoperative therapy is termed adjuvant. Trimodality therapy (chemotherapy, radiation, and surgery) has become the standard treatment regimen for resectable, locally advanced NSCLC. During the past 2 decades, several prospective, randomized, and nonrandomized studies have explored various regimens for preoperative treatment of NSCLC. The evaluation of potential candidates with NSCLC for neoadjuvant therapy as well as the currently available therapeutic regimens are reviewed.Entities:
Keywords: Chemotherapy; Lung cancer; N2 nodal disease; Neoadjuvant concurrent therapy; Preoperative therapy; Radiation therapy; Stage IIIA non–small cell lung cancer (NSCLC); Stage IIIA(N2)
Mesh：
Year: 2016 PMID： 27261916 DOI： 10.1016/j.soc.2016.02.010
Source DB: PubMed Journal: Surg Oncol Clin N Am ISSN： 1055-3207 Impact factor: 3.495