| Literature DB >> 27261831 |
Niels Voigt1, Dobromir Dobrev2.
Abstract
Atrial fibrillation (AF) is associated with increased morbidity and mortality. Atrial-selective potassium (K(+)) channel blockers may represent a novel therapeutic target. The best validated atrial-specific ion currents are the acetylcholine-activated inward-rectifier K(+) current IK,ACh and ultrarapidly activating delayed-rectifier K(+) current IKur. Two-pore domain and small-conductance Ca(2+)-activated K(+) channels and Kv1.1 channels may also contribute to the atrial repolarization. We review the molecular and electrophysiologic characteristics of atrial-selective K(+) channels and their potential pathophysiologic role in AF. We summarize currently available K(+) channel blockers focusing on the most important compounds.Entities:
Keywords: Atrial fibrillation; I(K,ACh); I(Kur); K2P channels; Kv1.1 channels; SK channels
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Year: 2016 PMID： 27261831 DOI： 10.1016/j.ccep.2016.02.005
Source DB: PubMed Journal: Card Electrophysiol Clin ISSN： 1877-9182