Literature DB >> 27260626

[Protection of corneal endothelium from apoptosis by gene and cell therapy].

T A Fuchsluger1.   

Abstract

Protection of corneal endothelium from apoptosis using gene and cell therapy is in a translational phase. This approach offers advantages for eye banking and after transplantation. Safe vehicles for gene or cell therapeutic transduction of corneal endothelium with nucleic acids are available. This strategy will be further developed in consultation with the Paul Ehrlich Institute and European regulatory authorities.

Keywords:  Apoptosis; Nanoparticles; Translation; Transplantation; Vectors

Mesh：

Year:  2016        PMID： 27260626     DOI： 10.1007/s00347-016-0295-8

Source DB:  PubMed          Journal:  Ophthalmologe        ISSN： 0941-293X            Impact factor:   1.059


  13 in total

1.  Predicting endothelial cell loss and long-term corneal graft survival.

Authors:  W John Armitage; Andrew D Dick; William M Bourne
Journal:  Invest Ophthalmol Vis Sci       Date:  2003-08       Impact factor: 4.799

2.  Is ex vivo adenovirus mediated gene transfer a therapeutic option for the treatment of corneal diseases?

Authors:  T Ritter; N Gong; U Pleyer
Journal:  Br J Ophthalmol       Date:  2005-06       Impact factor: 4.638

3.  A new tool for the transfection of corneal endothelial cells: calcium phosphate nanoparticles.

Authors:  Jun Hu; Anna Kovtun; Anke Tomaszewski; Bernhard B Singer; Berthold Seitz; Matthias Epple; Klaus-Peter Steuhl; Süleyman Ergün; Thomas Armin Fuchsluger
Journal:  Acta Biomater       Date:  2011-09-17       Impact factor: 8.947

4.  Cell death during corneal storage at 4 degrees C.

Authors:  A Komuro; D O Hodge; G J Gores; W M Bourne
Journal:  Invest Ophthalmol Vis Sci       Date:  1999-11       Impact factor: 4.799

5.  The corneal endothelium. Normal and pathologic structure and function.

Authors:  G O Waring; W M Bourne; H F Edelhauser; K R Kenyon
Journal:  Ophthalmology       Date:  1982-06       Impact factor: 12.079

6.  [Viral vectors for gene delivery to corneal endothelial cells].

Authors:  T A Fuchsluger; U Jurkunas; A Kazlauskas; R Dana
Journal:  Klin Monbl Augenheilkd       Date:  2011-06-07       Impact factor: 0.700

7.  Corneal endothelial cells are protected from apoptosis by gene therapy.

Authors:  Thomas A Fuchsluger; Ula Jurkunas; Andrius Kazlauskas; Reza Dana
Journal:  Hum Gene Ther       Date:  2011-03-17       Impact factor: 5.695

8.  Factors influencing the suitability of organ-cultured corneas for transplantation.

Authors:  W J Armitage; D L Easty
Journal:  Invest Ophthalmol Vis Sci       Date:  1997-01       Impact factor: 4.799

9.  Apoptosis in the endothelium of human corneas for transplantation.

Authors:  J Albon; A B Tullo; S Aktar; M E Boulton
Journal:  Invest Ophthalmol Vis Sci       Date:  2000-09       Impact factor: 4.799

10.  Proliferative response of corneal endothelial cells from young and older donors.

Authors:  Cheng Zhu; Nancy C Joyce
Journal:  Invest Ophthalmol Vis Sci       Date:  2004-06       Impact factor: 4.799
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  1 in total

Review 1.  [Critical endothelial procedures during posterior lamellar graft preparation and transplantation].

Authors:  T A Fuchsluger; F E Kruse; G Geerling
Journal:  Ophthalmologe       Date:  2017-08       Impact factor: 1.059
  1 in total

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