| Literature DB >> 27259496 |
N S Lin'kova1,2,3, A O Drobintseva4, O A Orlova5, E P Kuznetsova6, V O Polyakova5,4, I M Kvetnoy5,4, V Kh Khavinson5,7,8.
Abstract
The effect peptides KE, KED, AED and AEDG on proliferation (Ki-67), regeneration and aging (CD98hc), apoptosis (caspase-3), and extracellular matrix remodeling (MMP-9) in skin fibroblasts during their aging in culture were studied by immunofluorescent confocal microscopy. All studied peptides inhibited MMP-9 synthesis that increases during aging of skin fibroblasts and enhanced the expression of Ki-67 and CD98hc that are less intensively synthesized during cell aging. Peptides AED and AEDG suppressed caspase-dependent apoptosis that increases during aging of cell cultures.Entities:
Keywords: aging; cell cultures; short peptides; signal molecules; skin
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Year: 2016 PMID： 27259496 DOI： 10.1007/s10517-016-3370-x
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804