| Literature DB >> 2725828 |
R Sugita1, Y Sawa, S Nomura, S H Zorn, T Yamauchi.
Abstract
The effect of reserpine (2 mg/kg i.p.) on both locomotor activity and the turnover of dopamine metabolite in the rat nucleus accumbens was estimated by using an activity monitor (Animex) and by in vivo brain microdialysis. Three to five hours after reserpine administration locomotor activity was reduced and there was a concomitant increase in the level of the dopamine metabolite, homovanillic These findings suggest that depletion of dopamine from the nucleus accumbens may result in decreased locomotor activity. The data support the notion that dopamine in this tissue contributes to the control of locomotion.Entities:
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Year: 1989 PMID： 2725828 DOI： 10.1007/bf00971322
Source DB: PubMed Journal: Neurochem Res ISSN： 0364-3190 Impact factor: 3.996