Literature DB >> 27258137

The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats.

Karen E Larsen1, Adrián L Lifschitz2, Carlos E Lanusse2, Guillermo L Virkel3.   

Abstract

The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues. The AChE activity in brain was higher (p<0.05) than those observed in kidney (females: 2.2-fold; males: 1.9-fold), liver (females: 6-fold; males: 6.9-fold) and plasma (females: 14.7-fold; males: 25.3-fold). Enzyme activities were higher in presence of 10mM GLP compared to those measured at an equimolar concentration of the potent AChE inhibitor dichlorvos (DDVP). Moreover, IC50s for GLP resulted between 6×10(4)- and 6.8×10(5)-fold higher than those observed for DDVP. In conclusion, GLP is a weak inhibitor of AChE in rats.
Copyright © 2016 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  Acetylcholinesterase; Dichlorvos; Glyphosate; Rats

Mesh：

Substances：

Year:  2016        PMID： 27258137     DOI： 10.1016/j.etap.2016.05.012

Source DB:  PubMed          Journal:  Environ Toxicol Pharmacol        ISSN： 1382-6689            Impact factor:   4.860


  4 in total

Review 1.  Toxic Effects of Glyphosate on the Nervous System: A Systematic Review.

Authors:  Carmen Costas-Ferreira; Rafael Durán; Lilian R F Faro
Journal:  Int J Mol Sci       Date:  2022-04-21       Impact factor: 6.208

2.  Perinatal Glyphosate-Based Herbicide Exposure in Rats Alters Brain Antioxidant Status, Glutamate and Acetylcholine Metabolism and Affects Recognition Memory.

Authors:  Cristina Eugenia Gallegos; Carlos Javier Baier; Mariana Bartos; Cristina Bras; Sergio Domínguez; Nina Mónaco; Fernanda Gumilar; María Sofía Giménez; Alejandra Minetti
Journal:  Neurotox Res       Date:  2018-04-02       Impact factor: 3.911

3.  Decrease in Butyrylcholinesterase Accompanied by Intermediate-like Syndrome after Massive Ingestion of a Glyphosate-surfactant.

Authors:  Ikuto Takeuchi; Youichi Yanagawa; Hiroki Nagasawa; Kei Jitsuiki; Shunsuke Madokoro; Norihito Takahashi; Hiromichi Ohsaka; Kouhei Ishikawa; Kazuhiko Omori
Journal:  Intern Med       Date:  2019-06-27       Impact factor: 1.271

4.  Interaction between glyphosate pesticide and amphiphilic peptides for colorimetric analysis.

Authors:  Barbara B Gerbelli; Pedro L O Filho; Bruna Cortez; Pedro T Sodré; Mauricio D Coutinho-Neto; Ian W Hamley; Jani Seitsonen; Wendel A Alves
Journal:  Nanoscale Adv       Date:  2022-07-28
  4 in total

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