| Literature DB >> 27257830 |
Robert Fahed1, Federico Di Maria1, Charlotte Rosso2,3,4, Nader Sourour1, Vincent Degos5,3, Sandrine Deltour2, Flore Baronnet-Chauvet2,3, Anne Léger2, Sophie Crozier2, Joseph Gabrieli1,3, Yves Samson2,3,4, Jacques Chiras1,3, Frédéric Clarençon1,3.
Abstract
OBJECTIVE Contrary to acute ischemic stroke involving the anterior circulation, no randomized trial has yet demonstrated the safety and effectiveness of endovascular management in acute basilar artery occlusion (BAO). Recently developed thrombectomy devices, such as stentrievers and aspiration systems, have helped in improving the endovascular management of acute ischemic stroke. The authors sought to assess the impact of these devices in the endovascular treatment of acute BAO. METHODS A retrospective analysis of 34 consecutive patients treated in Pitié-Salpêtrière Hospital for acute BAO was carried out. All patients had undergone an endovascular procedure. In addition to the global results in terms of safety and effectiveness (recanalization rate and 3-month clinical outcome based on the modified Rankin Scale [mRS]), the authors aimed to determine if the patients treated with the most recently developed devices (i.e., the Solitaire stentriever or the ADAPT catheter) had better angiographic and clinical outcomes than those treated with older endovascular strategies. RESULTS The overall successful recanalization rate (thrombolysis in cerebral infarction score 2b-3) was 50% (17 of 34 patients). A good clinical outcome (mRS score 0-2 at 3-month follow-up) was achieved in 11 (32.3%) of 34 patients. The mortality rate at 3-month follow-up was 29.4% (10 of 34 patients). Patients treated with the Solitaire stentriever and the ADAPT catheter had a higher recanalization rate (12 [92.3%] of 13 patients vs 5 [23.8%] of 21 patients, p = 0.0002) and a shorter mean (± SD) procedure duration (88 ± 31 minutes vs 126 ± 58 minutes, p = 0.04) than patients treated with older devices. CONCLUSIONS The latest devices have improved the effectiveness of mechanical thrombectomy in acute BAO. Their use in further studies may help demonstrate a benefit in the endovascular management of acute BAO.Entities:
Keywords: BAO = basilar artery occlusion; CTA = CT angiography; DSA = digital subtraction angiography; DWI = diffusion-weighted imaging; DWI-pc-ASPECTS = DWI–posterior circulation–Alberta stroke program early CT score; IQR = interquartile range; IV = intravenous; MT = mechanical thrombectomy; NIHSS = National Institutes of Health Stroke Scale; RCT = randomized controlled trial; TICI = thrombolysis in cerebral infarction; TOAST = Trial of Org 10172 in Acute Stroke Treatment; VA = vertebral artery; basilar artery occlusion; endovascular; mRS = modified Rankin Scale; stent retriever; thrombectomy; vascular disorders
Mesh：
Year: 2016 PMID： 27257830 DOI： 10.3171/2016.2.JNS151983
Source DB: PubMed Journal: J Neurosurg ISSN： 0022-3085 Impact factor: 5.115