Literature DB >> 27256997

Lethargy and vision loss: successful management of rhinocerebral mucormycosis.

Ramzi Mulki1, Muhammad Masab1, Glenn Eiger1, Sarah Perloff2.   

Abstract

Rhinocerebral mucormycosis (RCM) is an angioinvasive fungal infection most often caused by Rhizopus oryzae It is usually associated with an underlying risk factor and is associated with a poor prognosis. There are no consensus guidelines on the optimal management of this aggressive disease; most management decisions are based on case reports and expert opinion. We report a successfully managed case of RCM in an insulin-dependent diabetic, initially presenting with a change in mental status, rapidly progressing to complete right eye blindness and ophthalmoplegia and complicated by multiple cerebral infarctions and abscesses. We describe the diagnostic approach and various therapeutic interventions undertaken to successfully manage our patient. 2016 BMJ Publishing Group Ltd.

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Year:  2016        PMID: 27256997      PMCID: PMC4904383          DOI: 10.1136/bcr-2016-215855

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  29 in total

1.  Invasive fungal infections in patients with hematologic malignancies in a tertiary care cancer center: an autopsy study over a 15-year period (1989-2003).

Authors:  Georgios Chamilos; Mario Luna; Russell E Lewis; Gerald P Bodey; Roy Chemaly; Jeffrey J Tarrand; Amar Safdar; Issam I Raad; Dimitrios P Kontoyiannis
Journal:  Haematologica       Date:  2006-06-01       Impact factor: 9.941

2.  Zygomycosis in the 1990s in a tertiary-care cancer center.

Authors:  D P Kontoyiannis; V C Wessel; G P Bodey; K V Rolston
Journal:  Clin Infect Dis       Date:  2000-06-13       Impact factor: 9.079

3.  Mucormycosis of the jaw after dental extractions: two case reports.

Authors:  Abdulaziz A Bakathir
Journal:  Sultan Qaboos Univ Med J       Date:  2006-12

Review 4.  Granulocyte colony-stimulating factor and other cytokines in antifungal therapy.

Authors:  E Roilides; E Farmaki
Journal:  Clin Microbiol Infect       Date:  2001       Impact factor: 8.067

5.  Liposomal amphotericin B for empirical therapy in patients with persistent fever and neutropenia. National Institute of Allergy and Infectious Diseases Mycoses Study Group.

Authors:  T J Walsh; R W Finberg; C Arndt; J Hiemenz; C Schwartz; D Bodensteiner; P Pappas; N Seibel; R N Greenberg; S Dummer; M Schuster; J S Holcenberg
Journal:  N Engl J Med       Date:  1999-03-11       Impact factor: 91.245

6.  Early diagnosis of rhinocerebral mucormycosis by cerebrospinal fluid analysis and determination of 16s rRNA gene sequence.

Authors:  D Bengel; M Susa; H Schreiber; A C Ludolph; H Tumani
Journal:  Eur J Neurol       Date:  2007-09       Impact factor: 6.089

Review 7.  Survival factors in rhino-orbital-cerebral mucormycosis.

Authors:  R A Yohai; J D Bullock; A A Aziz; R J Markert
Journal:  Surv Ophthalmol       Date:  1994 Jul-Aug       Impact factor: 6.048

Review 8.  Zygomycosis: conventional laboratory diagnosis.

Authors:  C Lass-Flörl
Journal:  Clin Microbiol Infect       Date:  2009-10       Impact factor: 8.067

9.  The iron chelator deferasirox protects mice from mucormycosis through iron starvation.

Authors:  Ashraf S Ibrahim; Teclegiorgis Gebermariam; Yue Fu; Lin Lin; Mohamed I Husseiny; Samuel W French; Julie Schwartz; Christopher D Skory; John E Edwards; Brad J Spellberg
Journal:  J Clin Invest       Date:  2007-09       Impact factor: 14.808

10.  Interferon-gamma and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children.

Authors:  Mark J Abzug; Thomas J Walsh
Journal:  Pediatr Infect Dis J       Date:  2004-08       Impact factor: 2.129

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  1 in total

1.  Case Report: Rhizopus arrhizus Rhino-Orbital-Cerebral Mycosis and Lethal Midline Granuloma: Another Fungal Etiological Agent.

Authors:  Dong Ming Li; Li De Lun; Jie Ge; Gong Jie Zhang; Xin Lun Li; G Sybren de Hoog
Journal:  Front Med (Lausanne)       Date:  2021-06-02
  1 in total

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