Literature DB >> 27256846

The BRPF2/BRD1-MOZ complex is involved in retinoic acid-induced differentiation of embryonic stem cells.

Hye In Cho1, Min Seong Kim1, Yeun Kyu Jang2.   

Abstract

The scaffold protein BRPF2 (also called BRD1), a key component of histone acetyltransferase complexes, plays an important role in embryonic development, but its function in the differentiation of embryonic stem cells (ESCs) remains unknown. In the present study, we investigated whether BRPF2 is involved in mouse ESC differentiation. BRPF2 depletion resulted in abnormal formation of embryoid bodies, downregulation of differentiation-associated genes, and persistent maintenance of alkaline phosphatase activity even after retinoic acid-induced differentiation, indicating impaired differentiation of BRPF2-depleted ESCs. We also found reduced global acetylation of histone H3 lysine 14 (H3K14) in BRPF2-depleted ESCs, irrespective of differentiation status. Further, co-immunoprecipitation analysis revealed a physical association between BRPF2 and the histone acetyltransferase MOZ in differentiated ESCs, suggesting the role of BRPF2-MOZ complexes in ESC differentiation. Together, these results suggest that BRPF2-MOZ complexes play an important role in the differentiation of ESCs via H3K14 acetylation.
Copyright © 2016 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  BRPF2; Differentiation; Embryonic stem cells; Histone acetylation; MOZ

Mesh：

Substances：

Year:  2016        PMID： 27256846     DOI： 10.1016/j.yexcr.2016.05.022

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  9 in total

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Authors:  Jina Lee; Min Seong Kim; Su Hyung Park; Yeun Kyu Jang
Journal:  Sci Rep       Date:  2018-01-10       Impact factor: 4.379

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Journal:  J Med Chem       Date:  2017-05-01       Impact factor: 7.446

4.  JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway.

Authors:  Min Seong Kim; Hye In Cho; Hee Jung Yoon; Ye-Hyeon Ahn; Eun Jung Park; Yan Hua Jin; Yeun Kyu Jang
Journal:  Sci Rep       Date:  2018-04-26       Impact factor: 4.379

5.  Reduced Brd1 expression leads to reversible depression-like behaviors and gene-expression changes in female mice.

Authors:  Anto P Rajkumar; Per Qvist; Julie G Donskov; Ross Lazarus; Jonatan Pallesen; Nicoletta Nava; Gudrun Winther; Nico Liebenberg; Sanne H la Cour; Veerle Paternoster; Tue Fryland; Johan Palmfeldt; Kim Fejgin; Arne Mørk; Mette Nyegaard; Bente Pakkenberg; Michael Didriksen; Jens R Nyengaard; Gregers Wegener; Ole Mors; Jane H Christensen; Anders D Børglum
Journal:  Transl Psychiatry       Date:  2020-07-17       Impact factor: 6.222

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Authors:  Veerle Paternoster; Cagla Cömert; Louise Sand Kirk; Sanne Hage la Cour; Tue Fryland; Paula Fernandez-Guerra; Magnus Stougaard; Jens Randel Nyengaard; Per Qvist; Peter Bross; Anders Dupont Børglum; Jane Hvarregaard Christensen
Journal:  Transl Psychiatry       Date:  2022-08-08       Impact factor: 7.989

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Authors:  Jordan Kuwik; Shana Wagner; Babu Sudhamalla; Ronald Debiec; Kabirul Islam
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8.  Hippo-YAP signaling controls lineage differentiation of mouse embryonic stem cells through modulating the formation of super-enhancers.

Authors:  Xiang Sun; Zhijun Ren; Yixian Cun; Cai Zhao; Xianglin Huang; Jiajian Zhou; Rong Hu; Xiaoxi Su; Lu Ji; Peng Li; King Lun Kingston Mak; Feng Gao; Yi Yang; He Xu; Junjun Ding; Nan Cao; Shuo Li; Wensheng Zhang; Ping Lan; Hao Sun; Jinkai Wang; Ping Yuan
Journal:  Nucleic Acids Res       Date:  2020-07-27       Impact factor: 16.971

9.  BRPF3-HUWE1-mediated regulation of MYST2 is required for differentiation and cell-cycle progression in embryonic stem cells.

Authors:  Hye In Cho; Min Seong Kim; Jina Lee; Byong Chul Yoo; Kyung Hee Kim; Kwang-Min Choe; Yeun Kyu Jang
Journal:  Cell Death Differ       Date:  2020-06-18       Impact factor: 12.067
  9 in total

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