Literature DB >> 2725525

A novel pathway for transversion mutation induced by dCTP misincorporation in a mutator strain of CHO cells.

G Phear1, M Meuth.   

Abstract

Intracellular imbalances of dCTP produce both T----C transitions and an unusual class of transversions (A----C) at the aprt locus of CHO cells. Our data suggest that this transversion pathway is the consequence of dCTP:T mispairs which are not efficiently proofread during DNA replication.

Entities:  

Mesh：

Substances：

Year:  1989        PMID： 2725525      PMCID： PMC362603          DOI： 10.1128/mcb.9.4.1810-1812.1989

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  24 in total

1.  DNA sequence analysis of spontaneous mutations at the aprt locus of hamster cells.

Authors:  J Nalbantoglu; G Phear; M Meuth
Journal:  Mol Cell Biol       Date:  1987-04       Impact factor: 4.272

2.  Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia.

Authors:  R K Saiki; S Scharf; F Faloona; K B Mullis; G T Horn; H A Erlich; N Arnheim
Journal:  Science       Date:  1985-12-20       Impact factor: 47.728

3.  Characterization of a mutator gene in Chinese hamster ovary cells.

Authors:  M Meuth; N L'Heureux-Huard; M Trudel
Journal:  Proc Natl Acad Sci U S A       Date:  1979-12       Impact factor: 11.205

4.  The genetic consequences of nucleotide precursor pool imbalance in mammalian cells.

Authors:  M Meuth
Journal:  Mutat Res       Date:  1984-04       Impact factor: 2.433

Review 5.  Fidelity of DNA synthesis.

Authors:  L A Loeb; T A Kunkel
Journal:  Annu Rev Biochem       Date:  1982       Impact factor: 23.643

6.  Biochemical characterization of the hamster thy mutator gene and its revertants.

Authors:  M Trudel; T Van Genechten; M Meuth
Journal:  J Biol Chem       Date:  1984-02-25       Impact factor: 5.157

7.  Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation.

Authors:  A R Fersht
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

8.  Mutator phenotypes in mammalian cell mutants with distinct biochemical defects and abnormal deoxyribonucleoside triphosphate pools.

Authors:  G Weinberg; B Ullman; D W Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

9.  DNA polymerase accuracy and spontaneous mutation rates: frequencies of purine.purine, purine.pyrimidine, and pyrimidine.pyrimidine mismatches during DNA replication.

Authors:  A R Fersht; J W Knill-Jones
Journal:  Proc Natl Acad Sci U S A       Date:  1981-07       Impact factor: 11.205

10.  Accuracy of DNA polymerase-alpha in copying natural DNA.

Authors:  F Grosse; G Krauss; J W Knill-Jones; A R Fersht
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
View more
  3 in total

1.  Cell cycle-dependent variations in deoxyribonucleotide metabolism among Chinese hamster cell lines bearing the Thy- mutator phenotype.

Authors:  B J Mun; C K Mathews
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

2.  Spontaneous mutation at the mtr locus in neurospora: the molecular spectrum in wild-type and a mutator strain.

Authors:  D Dillon; D Stadler
Journal:  Genetics       Date:  1994-09       Impact factor: 4.562

3.  Mechanisms of mutagenesis in vivo due to imbalanced dNTP pools.

Authors:  Dinesh Kumar; Amy L Abdulovic; Jörgen Viberg; Anna Karin Nilsson; Thomas A Kunkel; Andrei Chabes
Journal:  Nucleic Acids Res       Date:  2010-10-20       Impact factor: 16.971
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.