Sasirekha Ramani1, Nora Mamani, Rodolfo Villena, Ananda S Bandyopadhyay, Chris Gast, Alicia Sato, Daniel Laucirica, Ralf Clemens, Mary K Estes, Miguel L O'Ryan. 1. From the *Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas; †Faculty of Medicine, Microbiology and Mycology Program, Institute of Biomedical Sciences; ‡Faculty of Medicine, Department of Pediatrics, Exequiel González Cortes Hospital, Universidad de Chile, Santiago, Chile; §Bill & Melinda Gates Foundation, Seattle, WA; ¶Fred Hutchinson Cancer Research Center, Seattle, Washington; and ‖Global Research in Infectious Diseases, Rio de Janeiro, Brazil.
Abstract
BACKGROUND: Vaccine schedules including bivalent oral and inactivated poliovirus vaccines will replace trivalent oral poliovirus vaccines in 2016. METHODS: We evaluated rotavirus immunoglobulin A seroresponses when the second dose of Rotarix at 16 weeks was given concomitantly with inactivated or bivalent oral poliovirus vaccines. RESULTS:Rotavirus immunoglobulin A seroresponse rate at week 28 was 15% lower in recipients of bivalent oral poliovirus vaccines compared with inactivated poliovirus vaccines. CONCLUSION:Bivalent oral poliovirus vaccine decreases rotavirus IgA seroresponse rates when coadministered at 16 weeks of age.
RCT Entities:
BACKGROUND: Vaccine schedules including bivalent oral and inactivated poliovirus vaccines will replace trivalent oral poliovirus vaccines in 2016. METHODS: We evaluated rotavirus immunoglobulin A seroresponses when the second dose of Rotarix at 16 weeks was given concomitantly with inactivated or bivalent oral poliovirus vaccines. RESULTS: Rotavirus immunoglobulin A seroresponse rate at week 28 was 15% lower in recipients of bivalent oral poliovirus vaccines compared with inactivated poliovirus vaccines. CONCLUSION: Bivalent oral poliovirus vaccine decreases rotavirus IgA seroresponse rates when coadministered at 16 weeks of age.
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