| Literature DB >> 27253453 |
Pengfei Zhao1,2, Mingbin Zheng3,4,5, Zhenyu Luo1,2, Xiujun Fan6, Zonghai Sheng1, Ping Gong1, Ze Chen1, Baozhen Zhang6, Dapeng Ni1,2, Yifan Ma7, Lintao Cai8.
Abstract
Oxygen nanocarrier (A/D-ONC) with a polymeric core entrapping hemoglobin and a cationic lipid shell absorbing a DOX-intercalating DNA duplex is developed. After endocytosis oxygenated A/D-ONC donates O2 to cancer cells that acts therapeutically by: (1) increasing intracellular ATP content that promotes DOX release, thereby converting ATP to the trigger of detrimental chemotherapy; (2) by synchronously increasing the ROS amount to amplify the lethality to cancer cells.Entities:
Keywords: aptamers; cancer therapy; chemotherapy; mitochondria; oxygen nanocarrier
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Year: 2016 PMID： 27253453 DOI： 10.1002/adhm.201600121
Source DB: PubMed Journal: Adv Healthc Mater ISSN： 2192-2640 Impact factor: 9.933