Literature DB >> 27253071

Traumatic Brain Injury Imaging in the Second Near-Infrared Window with a Molecular Fluorophore.

Xiao-Dong Zhang1,2, Huasen Wang3, Alexander L Antaris1, Lulin Li4, Shuo Diao1, Rui Ma3, Andy Nguyen4, Guosong Hong1, Zhuoran Ma1, Joy Wang1, Shoujun Zhu1, Joseph M Castellano5, Tony Wyss-Coray5,6, Yongye Liang3, Jian Luo5,4, Hongjie Dai1.   

Abstract

Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. A bright, renal-excreted, and biocompatible near-infrared II fluorophore for in vivo imaging of TBI is designed. A transient hypoperfusion in the injured cerebral region, followed by fluorophore leakage, is observed. NIR-II fluorophores can provide noninvasive assessment of TBI.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  molecular fluorophores; near-infrared II fluorescence imaging; traumatic brain injury

Mesh：

Substances：

Year:  2016        PMID： 27253071      PMCID： PMC5293734          DOI： 10.1002/adma.201600706

Source DB:  PubMed          Journal:  Adv Mater        ISSN： 0935-9648            Impact factor:   30.849


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