Literature DB >> 27252743

Atraumatic intracapsular neck of femur fractures after prolonged bisphosphonate treatment: a new atypical variant?

Sameer Khalid Khan1, Terence Savaridas2, Jennifer S Hemers3, Zouheir Maarouf4, Jane M Orgee5, Michael M Orr6.   

Abstract

We present 2 cases of elderly females presenting with atraumatic, near-vertical (Pauwells grade 3), intracapsular neck of femur fractures. Following diagnosis of osteoporosis on DEXA scans, they had received alendronic acid for 7 and 10 years respectively. Routine blood tests and serum estimations of calcium, vitamin-D and thyroid-stimulating hormone, done at admission, were within the normal ranges. These patients were managed with a hemiarthroplasty and a dynamic hip screw (DHS) respectively, following discontinuation of bisphosphonates. We present these 2 cases in light of emerging evidence that associates long-term bisphosphonate use with atypical low energy femoral fractures. Only subtrochanteric/diaphyseal fractures have been reported to date. We present a new variant of atypical femoral neck fractures in metaphyseal bone related to prolonged bisphosphonate therapy.

Entities:  

Keywords:  atypical hip fractures; bisphosphonates; intracapsular fractures

Year:  2016        PMID: 27252743      PMCID: PMC4869952          DOI: 10.11138/ccmbm/2016.13.1.038

Source DB:  PubMed          Journal:  Clin Cases Miner Bone Metab        ISSN: 1724-8914


  13 in total

1.  Histological finding of atypical subtrochanteric fracture after long-term alendronate therapy.

Authors:  Yoshitomo Kajino; Tamon Kabata; Koji Watanabe; Hiroyuki Tsuchiya
Journal:  J Orthop Sci       Date:  2011-05-21       Impact factor: 1.601

2.  Severely suppressed bone turnover: a potential complication of alendronate therapy.

Authors:  Clarita V Odvina; Joseph E Zerwekh; D Sudhaker Rao; Naim Maalouf; Frank A Gottschalk; Charles Y C Pak
Journal:  J Clin Endocrinol Metab       Date:  2004-12-14       Impact factor: 5.958

3.  Human femoral neck has less cellular periosteum, and more mineralized periosteum, than femoral diaphyseal bone.

Authors:  Matthew R Allen; David B Burr
Journal:  Bone       Date:  2005-02       Impact factor: 4.398

4.  Bisphosphonate treatment suppresses not only stochastic remodeling but also the targeted repair of microdamage.

Authors:  J Li; T Mashiba; D B Burr
Journal:  Calcif Tissue Int       Date:  2001-11       Impact factor: 4.333

5.  Bilateral low-energy simultaneous or sequential femoral fractures in patients on long-term alendronate therapy.

Authors:  Craig M Capeci; Nirmal C Tejwani
Journal:  J Bone Joint Surg Am       Date:  2009-11       Impact factor: 5.284

6.  Low-energy femoral shaft fractures associated with alendronate use.

Authors:  Andrew S Neviaser; Joseph M Lane; Brett A Lenart; Folorunsho Edobor-Osula; Dean G Lorich
Journal:  J Orthop Trauma       Date:  2008 May-Jun       Impact factor: 2.512

7.  Change in bone turnover and hip, non-spine, and vertebral fracture in alendronate-treated women: the fracture intervention trial.

Authors:  Douglas C Bauer; Dennis M Black; Patrick Garnero; Marc Hochberg; Susan Ott; John Orloff; Desmond E Thompson; Susan K Ewing; Pierre D Delmas
Journal:  J Bone Miner Res       Date:  2004-05-24       Impact factor: 6.741

8.  Stress fractures of the femoral neck and coxa vara.

Authors:  P Carpintero; F Leon; M Zafra; J A Serrano-Trenas; M Román
Journal:  Arch Orthop Trauma Surg       Date:  2003-05-20       Impact factor: 3.067

9.  Three years of alendronate treatment results in similar levels of vertebral microdamage as after one year of treatment.

Authors:  Matthew R Allen; David B Burr
Journal:  J Bone Miner Res       Date:  2007-11       Impact factor: 6.741

10.  Histology of an undisplaced femoral fatigue fracture in association with bisphosphonate treatment. Frozen bone with remodelling at the crack.

Authors:  Per Aspenberg; Jörg Schilcher; Anna Fahlgren
Journal:  Acta Orthop       Date:  2010-08       Impact factor: 3.717

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  4 in total

1.  Atraumatic femoral neck fracture during bisphosphonate treatment: case report and review of the literature.

Authors:  Robert Wilk; Damian Kusz; Hanna Grygiel; Magdalena Grosiak; Jakub Kamiński; Marcin Kusz
Journal:  Aging Clin Exp Res       Date:  2017-10-27       Impact factor: 3.636

2.  Atypical incomplete femoral neck fracture in patients taking long-term bisphosphonate: Case report, a report of 2 cases.

Authors:  You-Sung Suh; Byung-Woong Jang; Jae-Hwi Nho; Sung-Hun Won; Won-Seok Lee
Journal:  Medicine (Baltimore)       Date:  2019-03       Impact factor: 1.889

3.  The enigma of atypical femoral fractures: A summary of current knowledge.

Authors:  Morten Schultz Larsen; Hagen Schmal
Journal:  EFORT Open Rev       Date:  2018-09-12

4.  Early detected femoral neck insufficiency fracture in a patient treated with long-term bisphosphonate therapy for osteoporosis: A need for MRI.

Authors:  Yoon Jae Seong; Jong Ki Shin; Won Ro Park
Journal:  Int J Surg Case Rep       Date:  2020-05-07
  4 in total

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