Literature DB >> 27251707

Early growth response-1 in the pathogenesis of cardiovascular disease.

Levon M Khachigian1.   

Abstract

This article reviews the regulatory roles of the immediate-early gene product and prototypic zinc finger transcription factor, early growth response-1 in models of cardiovascular pathobiology, focusing on insights using microRNA, DNAzymes, small hairpin RNA, small interfering RNA, oligonucleotide decoy strategies and mice deficient in early growth response-1.

Entities:  

Keywords:  Egr-1; Restenosis; Smooth muscle cells; Transcription factors

Mesh：

Substances：

Year:  2016        PMID： 27251707     DOI： 10.1007/s00109-016-1428-x

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  88 in total

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2.  A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.

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Journal:  Science       Date:  1987-11-06       Impact factor: 47.728

3.  Egr-1 is activated in endothelial cells exposed to fluid shear stress and interacts with a novel shear-stress-response element in the PDGF A-chain promoter.

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4.  Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial alpha-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats.

Authors:  H Nakamura; Y Isaka; M Tsujie; H D Rupprecht; Y Akagi; N Ueda; E Imai; M Hori
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5.  Interplay between EGR1 and SP1 is critical for 13-cis retinoic acid-mediated transcriptional repression of angiotensin type 1A receptor.

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6.  Suppression of transcription factor early growth response 1 reduces herpes simplex virus lethality in mice.

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7.  Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammation.

Authors:  Evis Harja; Loredana G Bucciarelli; Yan Lu; David M Stern; Yu Shan Zou; Ann Marie Schmidt; Shi-Fang Yan
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8.  Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits.

Authors:  K Ohtani; K Egashira; M Usui; M Ishibashi; K-I Hiasa; Q Zhao; M Aoki; Y Kaneda; R Morishita; A Takeshita
Journal:  Gene Ther       Date:  2004-01       Impact factor: 5.250

9.  Molecular cloning, sequencing, and mapping of EGR2, a human early growth response gene encoding a protein with "zinc-binding finger" structure.

Authors:  L J Joseph; M M Le Beau; G A Jamieson; S Acharya; T B Shows; J D Rowley; V P Sukhatme
Journal:  Proc Natl Acad Sci U S A       Date:  1988-10       Impact factor: 11.205

10.  Growth and differentiation proceeds normally in cells deficient in the immediate early gene NGFI-A.

Authors:  S L Lee; L C Tourtellotte; R L Wesselschmidt; J Milbrandt
Journal:  J Biol Chem       Date:  1995-04-28       Impact factor: 5.157
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  12 in total

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Authors:  Ahmad M N Alhendi; Margaret Patrikakis; Carsten O Daub; Hideya Kawaji; Masayoshi Itoh; Michiel de Hoon; Piero Carninci; Yoshihide Hayashizaki; Erik Arner; Levon M Khachigian
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2.  Egr-1 is involved in coronary microembolization-induced myocardial injury via Bim/Beclin-1 pathway-mediated autophagy inhibition and apoptosis activation.

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4.  Impaired cardiac performance, protein synthesis, and mitochondrial function in tumor-bearing mice.

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5.  MicroRNA-181a-2-3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson's disease by inhibiting EGR1 and NOX4.

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6.  Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR-138-5p-Mediated EGR1/TLR4/TRIF Inactivation.

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8.  miR-30e-3p Promotes Cardiomyocyte Autophagy and Inhibits Apoptosis via Regulating Egr-1 during Ischemia/Hypoxia.

Authors:  Bo Su; Xiantao Wang; Yuhan Sun; Manyun Long; Jing Zheng; Wenhao Wu; Lang Li
Journal:  Biomed Res Int       Date:  2020-08-17       Impact factor: 3.411

9.  Serine 26 in Early Growth Response-1 Is Critical for Endothelial Proliferation, Migration, and Network Formation.

Authors:  Fernando S Santiago; Yue Li; Levon M Khachigian
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10.  Agomelatine prevents angiotensin II-induced endothelial and mononuclear cell adhesion.

Authors:  Najiao Hong; Zhirong Ye; Yongjun Lin; Wensen Liu; Na Xu; Yan Wang
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