Samanta Lalic1,2, Kris M Jamsen3, Barbara C Wimmer3, Edwin C K Tan3, Sarah N Hilmer4,5, Leonie Robson6, Tina Emery6, J Simon Bell3,4,7. 1. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia. Samanta.Lalic@monash.edu. 2. Pharmacy Department, Austin Health, Melbourne, Melbourne, Australia. Samanta.Lalic@monash.edu. 3. Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Australia. 4. NHMRC Cognitive Decline Partnership Centre, Hornsby Ku-ring-gai Hospital, Hornsby, NSW, Australia. 5. Departments of Clinical Pharmacology and Aged Care, Kolling Institute of Medical Research, Sydney Medical School, Royal North Shore Hospital, The University of Sydney, Sydney, Australia. 6. Resthaven Incorporated, Adelaide, Australia. 7. Sansom Institute, School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia.
Abstract
PURPOSE: The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs). METHODS: A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer's disease (QoL-AD) scale. Covariates included age, sex, Charlson's comorbidity index, activities of daily living, and dementia severity. Logistic quantile regression was used to characterize the association between polypharmacy and QoL-AD (model 1) and MRCI and QoL-AD (model 2). RESULTS: The median age of the 383 residents was 88 years and 297 (78 %) residents were female. In total, 63 % of residents were exposed to polypharmacy and the median MRCI score (range) was 43.5 (4-113). After adjusting for the covariates, polypharmacy was not associated with either higher or lower QoL-AD scores (estimate -0.02; 95 % confidence interval (CI) -0.165, 0.124; p = 0.78). Similarly, after adjusting for the covariates, MRCI was not associated with either higher or lower QoL-AD scores (estimate -0.0009, 95 % CI -0.005, 0.003; p = 0.63). CONCLUSIONS: These findings suggest that polypharmacy and medication regimen complexity are not associated with staff informant rated HRQoL. Further research is needed to investigate how specific medication classes may impact change in quality of life over time.
PURPOSE: The purpose of this study is to investigate the association between polypharmacy with health-related quality of life (HRQoL) and medication regimen complexity with HRQoL in residential aged care facilities (RACFs). METHODS: A cross-sectional study of 383 residents from six Australian RACFs was conducted. The primary exposures were polypharmacy (≥9 regular medications) and the validated Medication Regimen Complexity Index (MRCI). The outcome measure was staff informant rated quality of life assessed using the Quality of Life Alzheimer's disease (QoL-AD) scale. Covariates included age, sex, Charlson's comorbidity index, activities of daily living, and dementia severity. Logistic quantile regression was used to characterize the association between polypharmacy and QoL-AD (model 1) and MRCI and QoL-AD (model 2). RESULTS: The median age of the 383 residents was 88 years and 297 (78 %) residents were female. In total, 63 % of residents were exposed to polypharmacy and the median MRCI score (range) was 43.5 (4-113). After adjusting for the covariates, polypharmacy was not associated with either higher or lower QoL-AD scores (estimate -0.02; 95 % confidence interval (CI) -0.165, 0.124; p = 0.78). Similarly, after adjusting for the covariates, MRCI was not associated with either higher or lower QoL-AD scores (estimate -0.0009, 95 % CI -0.005, 0.003; p = 0.63). CONCLUSIONS: These findings suggest that polypharmacy and medication regimen complexity are not associated with staff informant rated HRQoL. Further research is needed to investigate how specific medication classes may impact change in quality of life over time.
Entities:
Keywords:
Medication regimen complexity; Nursing homes; Polypharmacy; Quality of life; Residential aged care
Authors: Angela M Sanford; Martin Orrell; Debbie Tolson; Angela Marie Abbatecola; Hidenori Arai; Juergen M Bauer; Alfonso J Cruz-Jentoft; Birong Dong; Hyuk Ga; Ashish Goel; Ramzi Hajjar; Iva Holmerova; Paul R Katz; Raymond T C M Koopmans; Yves Rolland; Renuka Visvanathan; Jean Woo; John E Morley; Bruno Vellas Journal: J Am Med Dir Assoc Date: 2015-03 Impact factor: 4.669
Authors: Danijela Gnjidic; Sarah N Hilmer; Fiona M Blyth; Vasi Naganathan; Louise Waite; Markus J Seibel; Andrew J McLachlan; Robert G Cumming; David J Handelsman; David G Le Couteur Journal: J Clin Epidemiol Date: 2012-06-27 Impact factor: 6.437
Authors: Elizabeth Beattie; Maria O'Reilly; Wendy Moyle; Lynn Chenoweth; Deirdre Fetherstonhaugh; Barbara Horner; Andrew Robinson; Elaine Fielding Journal: Int Psychogeriatr Date: 2015-04-22 Impact factor: 3.878
Authors: Ana Margarida Advinha; Sofia de Oliveira-Martins; Vanessa Mateus; Sara Grou Pajote; Manuel José Lopes Journal: Int J Clin Pharm Date: 2014-06-07
Authors: Barbara Caecilia Wimmer; Kristina Johnell; Johan Fastbom; Michael David Wiese; J Simon Bell Journal: Eur J Clin Pharmacol Date: 2015-06-14 Impact factor: 2.953
Authors: Wijnanda J Frenkel; Erika J Jongerius; Miranda J Mandjes-van Uitert; Barbara C van Munster; Sophia E de Rooij Journal: J Am Geriatr Soc Date: 2014-01-21 Impact factor: 5.562
Authors: Edwin C K Tan; Renuka Visvanathan; Sarah N Hilmer; Tina Emery; Leonie Robson; Agnes I Vitry; Jessica M Hughes; Mary J Jones; Sarah Moawad; Jenni Ilomäki; Tara Quirke; J Simon Bell Journal: Drugs Aging Date: 2015-12 Impact factor: 3.923
Authors: Mary D Naylor; Karen B Hirschman; Alexandra L Hanlon; Katherine M Abbott; Kathryn H Bowles; Janice Foust; Shivani Shah; Cynthia Zubritsky Journal: J Am Med Dir Assoc Date: 2015-09-26 Impact factor: 4.669
Authors: Yael Schenker; Seo Young Park; Kwonho Jeong; Jennifer Pruskowski; Dio Kavalieratos; Judith Resick; Amy Abernethy; Jean S Kutner Journal: J Gen Intern Med Date: 2019-02-04 Impact factor: 5.128
Authors: Michael R Cobretti; Robert L Page; Sunny A Linnebur; Kimberly M Deininger; Amrut V Ambardekar; JoAnn Lindenfeld; Christina L Aquilante Journal: Clin Interv Aging Date: 2017-04-12 Impact factor: 4.458
Authors: Esa Yh Chen; J Simon Bell; Jenni Ilomaki; Claire Keen; Megan Corlis; Michelle Hogan; Jan Van Emden; Sarah N Hilmer; Janet K Sluggett Journal: Clin Interv Aging Date: 2019-10-22 Impact factor: 4.458
Authors: Mohammed A Mohammed; Rebekah J Moles; Sarah N Hilmer; Lisa Kouladjian O'Donnel; Timothy F Chen Journal: BMJ Open Date: 2018-01-11 Impact factor: 2.692
Authors: Netsanet A Negewo; Peter G Gibson; Peter Ab Wark; Jodie L Simpson; Vanessa M McDonald Journal: Int J Chron Obstruct Pulmon Dis Date: 2017-10-06