INTRODUCTION: MicroRNAs are non-coding RNAs that regulate the gene expression at post-transcriptional level. This futuristic study characterized the contribution of miR-1287 to the colorectal cancer (CRC) tumorigenesis. METHODS: The real-time reverse transcription-polymerase chain reaction was used to examine miR-1287 expression levels, prospectively in 40 pairs of CRC tissue samples and adjacent noncancerous tissues (>2 cm from cancer tissue). RESULTS: No significant relationship was found between miR-1287 expression levels and clinicopathological features. Showing significant changes overall, MiR-1287 was significantly upregulated in the group of CRC samples compared with matched noncancerous tissue samples. A receiver operating characteristic (ROC) curve also showed ROC area (AROC) of 34 % with 1.0 and 0.02 sensitivity and specificity, respectively. Expression of miR-1287, with a value of 0.34, P value = 1.98, and P > 0.05, revealed that this microRNA has a low sensitivity and specificity to be regarded as a tumor marker. CONCLUSIONS: With regard to recent increased rate of CRC in the world, the present study may be a contribution, though very small, in the diagnosis and consequently in the treatment of CRC patients.
INTRODUCTION: MicroRNAs are non-coding RNAs that regulate the gene expression at post-transcriptional level. This futuristic study characterized the contribution of miR-1287 to the colorectal cancer (CRC) tumorigenesis. METHODS: The real-time reverse transcription-polymerase chain reaction was used to examine miR-1287 expression levels, prospectively in 40 pairs of CRC tissue samples and adjacent noncancerous tissues (>2 cm from cancer tissue). RESULTS: No significant relationship was found between miR-1287 expression levels and clinicopathological features. Showing significant changes overall, MiR-1287 was significantly upregulated in the group of CRC samples compared with matched noncancerous tissue samples. A receiver operating characteristic (ROC) curve also showed ROC area (AROC) of 34 % with 1.0 and 0.02 sensitivity and specificity, respectively. Expression of miR-1287, with a value of 0.34, P value = 1.98, and P > 0.05, revealed that this microRNA has a low sensitivity and specificity to be regarded as a tumor marker. CONCLUSIONS: With regard to recent increased rate of CRC in the world, the present study may be a contribution, though very small, in the diagnosis and consequently in the treatment of CRC patients.
Authors: Weixin Wang; Meghan Corrigan-Cummins; Justin Hudson; Irina Maric; Olga Simakova; Sattva S Neelapu; Larry W Kwak; John E Janik; Barry Gause; Elaine S Jaffe; Katherine R Calvo Journal: Haematologica Date: 2011-11-18 Impact factor: 9.941
Authors: Jie Shen; Dan Wang; Steven R Gregory; Leonard Medico; Qiang Hu; Li Yan; Kunle Odunsi; Shashikant B Lele; Christine B Ambrosone; Song Liu; Hua Zhao Journal: Carcinogenesis Date: 2012-01-10 Impact factor: 4.944
Authors: Narayan Shivapurkar; Louis M Weiner; John L Marshall; Subha Madhavan; Anne Deslattes Mays; Hartmut Juhl; Anton Wellstein Journal: PLoS One Date: 2014-01-06 Impact factor: 3.240
Authors: Yaguang Xi; Andrea Formentini; Minchen Chien; David B Weir; James J Russo; Jingyue Ju; Marko Kornmann; Jingfang Ju Journal: Biomark Insights Date: 2006
Authors: Fiona C Malcomson; Naomi D Willis; Iain McCallum; Long Xie; Bart Lagerwaard; Seamus Kelly; D Michael Bradburn; Nigel J Belshaw; Ian T Johnson; John C Mathers Journal: Mol Carcinog Date: 2017-05-09 Impact factor: 4.784