Tapas Kumar Banerjee1, Saunak Dutta2, Sujata Das3, Malay Ghosal4, Biman Kanti Ray5, Atanu Biswas3, Avijit Hazra6, Arijit Chaudhuri7, Neelanjana Paul8, Shyamal Kumar Das3. 1. Department of Neurology, National Neuroscience Centre, Kolkata, India. 2. Department of Statistics, University of Calcutta Ballygunj Campus, Kolkata, India. 3. Department of Neurology, Bangur Institute of Neurosciences, Kolkata, India. 4. Department of Psychiatry, Medical College Kolkata, Kolkata, India. 5. Department of Neurology, R. G. Kar Medical College, Kolkata, India. 6. Department of Pharmacology, Institute of Post Graduate Medical Education and Research (IPGME&R), Kolkata, India. 7. Sampling Unit, Department of Applied Statistics, Indian Statistical Institute, Kolkata, India. 8. Department of psychiatry, ICARE Institute of Medical Sciences & Research, Haldia, West Bengal, India.
Abstract
OBJECTIVES: Increase in aging population is expected to lead to increasing prevalence of dementia in India. In this study, we aimed to determine prevalence, incidence, and mortality of dementia and its subtypes and assess dementia burden in terms of disability-adjusted life years (DALY). METHODS: A community study was conducted over 5 years (2003-2008) in Kolkata, India, on 100,802 (males 53,209) randomly selected subjects to assess prevalence and capture data on incident cases and deaths. Standard case definitions were used. The data were used to estimate years of life lost (YLL) due to premature mortality, years of life lived with disability (YLD), and DALY, based on Global Burden of Disease 2010 approach. RESULTS: During 2003-2004, there were 103 (men 55) cases of dementia. The prevalence was 1.53% (age adjusted 1.12%) at age ≥65 years. In those ≥55 years age, average annual incidence rate of dementia was 72.57 per 100,000. All-cause standardized mortality ratio in dementia cases was 4.74 (men 6.19, women 3.03). The burden of dementia in 2007-2008 revealed that overall YLL was 47.13 per 100,000 and YLD ranged from 1.87 to 16.95 per 100,000 depending on the clinical severity of dementia. The overall DALY lost per 100,000 due to dementia for the year 2007-2008 was 74.19. CONCLUSIONS: This community study revealed a low prevalence and incidence of dementia with consequent low DALY-derived burden of illness compared with many industrialized nations. YLL formed major component of DALY indicating premature mortality to be an outcome of dementia burden.
OBJECTIVES: Increase in aging population is expected to lead to increasing prevalence of dementia in India. In this study, we aimed to determine prevalence, incidence, and mortality of dementia and its subtypes and assess dementia burden in terms of disability-adjusted life years (DALY). METHODS: A community study was conducted over 5 years (2003-2008) in Kolkata, India, on 100,802 (males 53,209) randomly selected subjects to assess prevalence and capture data on incident cases and deaths. Standard case definitions were used. The data were used to estimate years of life lost (YLL) due to premature mortality, years of life lived with disability (YLD), and DALY, based on Global Burden of Disease 2010 approach. RESULTS: During 2003-2004, there were 103 (men 55) cases of dementia. The prevalence was 1.53% (age adjusted 1.12%) at age ≥65 years. In those ≥55 years age, average annual incidence rate of dementia was 72.57 per 100,000. All-cause standardized mortality ratio in dementia cases was 4.74 (men 6.19, women 3.03). The burden of dementia in 2007-2008 revealed that overall YLL was 47.13 per 100,000 and YLD ranged from 1.87 to 16.95 per 100,000 depending on the clinical severity of dementia. The overall DALY lost per 100,000 due to dementia for the year 2007-2008 was 74.19. CONCLUSIONS: This community study revealed a low prevalence and incidence of dementia with consequent low DALY-derived burden of illness compared with many industrialized nations. YLL formed major component of DALY indicating premature mortality to be an outcome of dementia burden.
Authors: Adrienne N Poon; Yawen Xiang; Yelena Zavalishina; Shant Ayanian; Christopher F Aitken; Andrew C Procter; Igor Rudan; Kit Yee Chan Journal: J Glob Health Date: 2020-12 Impact factor: 4.413