| Literature DB >> 27250723 |
Arantxa Hervas1, Amparo Ruiz-Sauri2, Jose Gavara1, Jose V Monmeneu3, Elena de Dios1, Cesar Rios-Navarro1, Nerea Perez-Sole1, Itziar Perez4, Daniel Monleon5, Jose M Morales5,6, Gema Minana1, Julio Nunez1, Clara Bonanad1, Ana Diaz7, Jose M Vila8, Francisco J Chorro1, Vicente Bodi9.
Abstract
In extensive nonreperfused myocardial infarction (MI), remote fibrosis has been documented. Early reperfusion by primary angioplasty represents the gold standard method to minimize the extension of the infarction. We aimed to ascertain whether fibrosis also affects remote regions in reperfused MI in swine and patients. Swine were subjected to a transient occlusion of the left anterior descending artery followed by 1-week or 1-month reperfusion. Collagen content in the remote area macroscopically, microscopically, by magnetic resonance microimaging, and at the molecular level was similar to controls. In patients with previous MI, samples from autopsies displayed a significant increase in collagen content only in the infarct region. In patients with previous MI submitted to cardiac magnetic resonance-T1 mapping, the extracellular volume fraction in remote segments was similar to that for controls. In all scenarios, the remote region did not show a significant increase of collagen content in comparison with controls.Entities:
Keywords: Myocardial infarction; Remote fibrosis; Reperfusion; Swine model
Mesh：
Substances：
Year: 2016 PMID： 27250723 DOI： 10.1007/s12265-016-9698-9
Source DB: PubMed Journal: J Cardiovasc Transl Res ISSN： 1937-5387 Impact factor: 4.132