BACKGROUND: Patients undergoing arthroplasty require appropriate postsurgical pain relief. Analgesia is typically achieved through bolus doses of short-acting local anesthetics and with oral analgesics such as opiates, which are associated with systemic side effects. By formulating an injectable thermosensitive gelling system containing lidocaine, sustained and local delivery can be achieved following a single administration. RESULTS: Poloxamer-based thermosensitive gelling formulations were prepared. Altering the weight ratios of poloxamers affected the sol-to-gel transition temperature, mechanical and rheological properties and in vitro drug release. Desirable formulations gelled between 28 and 33°C providing sustained release of lidocaine over 48 h. CONCLUSION: Thermosensitive gelling systems are promising for sustained drug release following patient administration and may be beneficial in addressing postoperative pain.
BACKGROUND:Patients undergoing arthroplasty require appropriate postsurgical pain relief. Analgesia is typically achieved through bolus doses of short-acting local anesthetics and with oral analgesics such as opiates, which are associated with systemic side effects. By formulating an injectable thermosensitive gelling system containing lidocaine, sustained and local delivery can be achieved following a single administration. RESULTS: Poloxamer-based thermosensitive gelling formulations were prepared. Altering the weight ratios of poloxamers affected the sol-to-gel transition temperature, mechanical and rheological properties and in vitro drug release. Desirable formulations gelled between 28 and 33°C providing sustained release of lidocaine over 48 h. CONCLUSION: Thermosensitive gelling systems are promising for sustained drug release following patient administration and may be beneficial in addressing postoperative pain.
Entities:
Keywords:
arthroplasty; in situ gelling system; poloxamers; sol–gel transition; surgery; sustained release; thermoreversible; thermosensitive; total joint replacement
Authors: Prabhat Bhusal; Jamie Lee Rahiri; Bruce Sua; Jessica E McDonald; Mahima Bansal; Sara Hanning; Manisha Sharma; Kaushik Chandramouli; Jeff Harrison; Georgina Procter; Gavin Andrews; David S Jones; Andrew G Hill; Darren Svirskis Journal: Drug Deliv Transl Res Date: 2018-06 Impact factor: 4.617
Authors: Manisha Sharma; Kaushik Chandramouli; Louise Curley; Beau Pontre; Keryn Reilly; Jacob Munro; Andrew Hill; Simon Young; Darren Svirskis Journal: Drug Deliv Transl Res Date: 2018-06 Impact factor: 4.617