Tsukasa Satou1, Hitoshi Ishikawa1,2, Ken Asakawa2, Toshiaki Goseki1, Kimiya Shimizu1. 1. a Department of Ophthalmology , Kitasato University School of Medicine , Sagamihara , Kanagawa , Japan. 2. b Department of Orthoptics and Visual Science , Kitasato University School of Allied Health Sciences , Sagamihara , Kanagawa , Japan.
Abstract
PURPOSE: We investigated the effects of instillation of ripasudil hydrochloride hydrate (GLANATEC®) on pupil dynamics. MATERIALS AND METHODS: Fourteen healthy participants (mean age: 30 years), who had no ophthalmic diseases other than refractive error, were enrolled in this study. A single dose of GLANATEC® was instilled into the left eye only. The pupillary response was measured before and 30 and 120 min after instillation; we also measured intraocular pressure (IOP) at the same time points. RESULTS: The IOP in the left eye was significantly lower at both 30 (p < 0.05) and 120 (p < 0.01) min after instillation than at baseline, whereas that in the right eye was not significantly different from baseline at either of the measured post-instillation time points. In contrast, the pupillary response did not significantly differ between the three time points. CONCLUSIONS: A single instillation of low concentration GLANATEC® may have no effect on pupil diameter and pupillary response.
PURPOSE: We investigated the effects of instillation of ripasudil hydrochloride hydrate (GLANATEC®) on pupil dynamics. MATERIALS AND METHODS: Fourteen healthy participants (mean age: 30 years), who had no ophthalmic diseases other than refractive error, were enrolled in this study. A single dose of GLANATEC® was instilled into the left eye only. The pupillary response was measured before and 30 and 120 min after instillation; we also measured intraocular pressure (IOP) at the same time points. RESULTS: The IOP in the left eye was significantly lower at both 30 (p < 0.05) and 120 (p < 0.01) min after instillation than at baseline, whereas that in the right eye was not significantly different from baseline at either of the measured post-instillation time points. In contrast, the pupillary response did not significantly differ between the three time points. CONCLUSIONS: A single instillation of low concentration GLANATEC® may have no effect on pupil diameter and pupillary response.