| Literature DB >> 27247343 |
Thomas J Scriba1, Stefan H E Kaufmann2, Paul Henri Lambert3, Melvin Sanicas4, Carlos Martin5, Olivier Neyrolles6.
Abstract
Live attenuated and killed whole-cell vaccines (WCVs) offer promising vaccination strategies against tuberculosis. A number of WCV candidates, based on recombinant bacillus Calmette-Guerin (BCG), attenuated Mycobacterium tuberculosis, or related mycobacterial species are in various stages of preclinical or clinical development. In this review, we discuss the vaccine candidates and key factors shaping the development pathway for live and killed WCVs and provide an update on progress.Entities:
Keywords: BCG; tuberculosis; vaccine; whole-cell vaccine
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Year: 2016 PMID: 27247343 DOI: 10.1093/infdis/jiw228
Source DB: PubMed Journal: J Infect Dis ISSN: 0022-1899 Impact factor: 5.226