Erwan Stéphan-Blanchard1, Karen Chardon2, Djamal-Dine Djeddi3, André Léké4, Stéphane Delanaud2, Véronique Bach2, Frédéric Telliez2. 1. PériTox Laboratory UMR-I-01, University of Picardy Jules Verne, Amiens, France. Electronic address: erwan.stephan@u-picardie.fr. 2. PériTox Laboratory UMR-I-01, University of Picardy Jules Verne, Amiens, France. 3. PériTox Laboratory UMR-I-01, University of Picardy Jules Verne, Amiens, France; Pediatric Gastro-enterology Unit, Amiens University Hospital, Amiens, France. 4. PériTox Laboratory UMR-I-01, University of Picardy Jules Verne, Amiens, France; Neonatal and Pediatric Intensive Care Unit, Amiens University Hospital, Amiens, France.
Abstract
OBJECTIVE: We aimed to determine whether in utero exposure to smoking may influence the activity and dynamics of cardiac autonomic control in preterm infants. We hypothesized that cardiac autonomic control is altered in preterm infants exposed prenatally to smoking and that these effects may vary as a function of the sleep state. METHODS: We studied healthy, preterm neonates born to mothers who had smoked throughout pregnancy but not since birth (n=16). In utero-exposed neonates were matched with control preterm neonates born to non-smoking mothers (n=18). Cardiac autonomic control was monitored as a function of the sleep state by assessing heart rate variability with both linear and non-linear methods. RESULTS: Preterm neonates with in utero exposure to smoking displayed alterations (relative to control neonates) in short-term cardiac autonomic control in all sleep states. These alterations included low vagal activity, elevated sympathetic activity, and low complexity and adaptability in heart rate control dynamics. CONCLUSIONS: Our results constitute direct evidence that cardiac autonomic activity and control are altered in sleeping preterm infants exposed to smoking in utero. SIGNIFICANCE: These alterations may place the affected infants at a higher risk of neurological and cardiovascular complications, which could conceivably persist throughout childhood and adulthood.
OBJECTIVE: We aimed to determine whether in utero exposure to smoking may influence the activity and dynamics of cardiac autonomic control in preterm infants. We hypothesized that cardiac autonomic control is altered in preterm infants exposed prenatally to smoking and that these effects may vary as a function of the sleep state. METHODS: We studied healthy, preterm neonates born to mothers who had smoked throughout pregnancy but not since birth (n=16). In utero-exposed neonates were matched with control preterm neonates born to non-smoking mothers (n=18). Cardiac autonomic control was monitored as a function of the sleep state by assessing heart rate variability with both linear and non-linear methods. RESULTS: Preterm neonates with in utero exposure to smoking displayed alterations (relative to control neonates) in short-term cardiac autonomic control in all sleep states. These alterations included low vagal activity, elevated sympathetic activity, and low complexity and adaptability in heart rate control dynamics. CONCLUSIONS: Our results constitute direct evidence that cardiac autonomic activity and control are altered in sleeping preterm infants exposed to smoking in utero. SIGNIFICANCE: These alterations may place the affected infants at a higher risk of neurological and cardiovascular complications, which could conceivably persist throughout childhood and adulthood.
Authors: Amanda N Noroña-Zhou; Michael Coccia; Elissa Epel; Cassandra Vieten; Nancy E Adler; Barbara Laraia; Karen Jones-Mason; Abbey Alkon; Nicole R Bush Journal: Psychosom Med Date: 2022-03-10 Impact factor: 3.864