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Literature DB >> 27246776

Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing.

Hongfei Mi¹, Dai Wang², Yunxin Xue², Zhi Zhang², Jianjun Niu³, Yuzhi Hong⁴, Karl Drlica⁴, Xilin Zhao⁵.

Abstract

The contribution of reactive oxygen species (ROS) to antimicrobial lethality was examined by treating Escherichia coli with dimethyl sulfoxide (DMSO), an antioxidant solvent frequently used in antimicrobial studies. DMSO inhibited killing by ampicillin, kanamycin, and two quinolones and had little effect on MICs. DMSO-mediated protection correlated with decreased ROS accumulation and provided evidence for ROS-mediated programmed cell death. These data support the contribution of ROS to antimicrobial lethality and suggest caution when using DMSO-dissolved antimicrobials for short-time killing assays.

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Year: 2016 PMID： 27246776 PMCID： PMC4958201 DOI： 10.1128/AAC.03003-15

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

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